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dc.contributor.authorSolis-Urra, Patricio
dc.contributor.authorMolina-Hidalgo, Cristina
dc.contributor.authorGarcía-Rivero, Yolanda
dc.contributor.authorCosta-Rodriguez, Claudia
dc.contributor.authorMora-Gonzalez, Jose
dc.contributor.authorFernandez-Gamez, Beatriz
dc.contributor.authorOlvera-Rojas, Marcos
dc.contributor.authorCoca-Pulido, Andrea
dc.contributor.authorToval, Angel
dc.contributor.authorBellón, Darío
dc.contributor.authorSclafani, Alessandro
dc.contributor.authorMartín-Fuentes, Isabel
dc.contributor.authorTriviño-Ibañez, Eva María
dc.contributor.authorde Teresa, Carlos
dc.contributor.authorHuang, Haiqing
dc.contributor.authorGrove, George
dc.contributor.authorHillman, Charles H.
dc.contributor.authorKramer, Arthur F.
dc.contributor.authorCatena, Andrés
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorGómez-Río, Manuel
dc.contributor.authorErickson, Kirk I.
dc.contributor.authorEsteban-Cornejo, Irene
dc.date.accessioned2023-10-24T07:26:09Z
dc.date.available2023-10-24T07:26:09Z
dc.date.issued2023
dc.identifier.citationSolis-Urra, P., Molina-Hidalgo, C., García-Rivero, Y., Costa-Rodriguez, C., Mora-Gonzalez, J., Fernandez-Gamez, B., Olvera-Rojas, M., Coca-Pulido, A., Toval, A., Bellón, D., Sclafani, A., Martín-Fuentes, I., Triviño-Ibañez, E. M., de Teresa, C., Huang, H., Grove, G., Hillman, C. H., Kramer, A. F., Catena, A., . . . Esteban-Cornejo, I. (2023). Active Gains in brain Using Exercise During Aging (AGUEDA) : protocol for a randomized controlled trial. <i>Frontiers in Human Neuroscience</i>, <i>17</i>, Article 1168549. <a href="https://doi.org/10.3389/fnhum.2023.1168549" target="_blank">https://doi.org/10.3389/fnhum.2023.1168549</a>
dc.identifier.otherCONVID_193470869
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/90585
dc.description.abstractAlzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65–80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.ispartofseriesFrontiers in Human Neuroscience
dc.rightsCC BY 4.0
dc.subject.otherexercise
dc.subject.otherexecutive function
dc.subject.otherAlzheimer’s disease
dc.subject.otheramyloid beta
dc.subject.otherbrain
dc.titleActive Gains in brain Using Exercise During Aging (AGUEDA) : protocol for a randomized controlled trial
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202310246616
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_dcae04bc
dc.description.reviewstatuspeerReviewed
dc.relation.issn1662-5161
dc.relation.volume17
dc.type.versionpublishedVersion
dc.rights.copyright© 2023 Solis-Urra, Molina-Hidalgo, García-Rivero, Costa-Rodriguez, Mora-Gonzalez, Fernandez-Gamez, Olvera-Rojas, Coca-Pulido, Toval, Bellón, Sclafani, Martín-Fuentes, Triviño-Ibañez, de Teresa, Huang, Grove, Hillman, Kramer, Catena, Ortega, Gómez-Río, Erickson and Esteban-Cornejo
dc.rights.accesslevelopenAccessfi
dc.subject.ysoikääntyminen
dc.subject.ysokognitiiviset prosessit
dc.subject.ysoAlzheimerin tauti
dc.subject.ysodementia
dc.subject.ysoliikunta
dc.subject.ysoaivot
dc.subject.ysoharjoittelu
dc.subject.ysotoimintakyky
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p5283
jyx.subject.urihttp://www.yso.fi/onto/yso/p8412
jyx.subject.urihttp://www.yso.fi/onto/yso/p1711
jyx.subject.urihttp://www.yso.fi/onto/yso/p916
jyx.subject.urihttp://www.yso.fi/onto/yso/p7040
jyx.subject.urihttp://www.yso.fi/onto/yso/p26412
jyx.subject.urihttp://www.yso.fi/onto/yso/p10213
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fnhum.2023.1168549
jyx.fundinginformationThis study was supported by grant RTI2018-095284-J-100 funded by MCIN/AEI/10.13039/501100011033/ and “ERDF A way of making Europe”, and RYC2019-027287-I funded by MCIN/AEI/10.13039/501100011033/ and “ESF Investing in your future”. PS-U was supported by a “Margarita Salas” grant from the Spanish Ministry Universities. Plan Andaluz de Investigación (PAIDI) (Convocatoria 2020, Ref: P20_00124) 2021–2022. Ministerio de Economía y Competitividad–Proyectos I + D + I RETOS (Convocatoria 2020, Ref: PID2020-120249RB-I00). EXERNET Research Network on Exercise and Health (DEP2005-00046/ACTI; 09/UPB/19; 45/UPB/20; 27/UPB/21). University of Granada “Proyectos de investigación precompetitivos para jóvenes investigadores” (Convocatoria 2021, Ref: PPJIA2021-39). The sponsors had no role in the design and conduct of the study, in the collection, analysis, and interpretation of data, in the preparation of the manuscript or in the review or approval of the manuscript. His work is part of Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain.
dc.type.okmA2


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