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dc.contributor.authorKarjula, Topias
dc.contributor.authorNiskakangas, Anne
dc.contributor.authorMustonen, Olli
dc.contributor.authorPuro, Iiris
dc.contributor.authorElomaa, Hanna
dc.contributor.authorAhtiainen, Maarit
dc.contributor.authorKuopio, Teijo
dc.contributor.authorMecklin, Jukka-Pekka
dc.contributor.authorSeppälä, Toni T.
dc.contributor.authorWirta, Erkki-Ville
dc.contributor.authorSihvo, Eero
dc.contributor.authorYannopoulos, Fredrik
dc.contributor.authorHelminen, Olli
dc.contributor.authorVäyrynen, Juha P.
dc.date.accessioned2023-06-21T10:06:52Z
dc.date.available2023-06-21T10:06:52Z
dc.date.issued2023
dc.identifier.citationKarjula, T., Niskakangas, A., Mustonen, O., Puro, I., Elomaa, H., Ahtiainen, M., Kuopio, T., Mecklin, J.-P., Seppälä, T. T., Wirta, E.-V., Sihvo, E., Yannopoulos, F., Helminen, O., & Väyrynen, J. P. (2023). Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer. <i>Virchows Archiv</i>, <i>483</i>, 21-32. <a href="https://doi.org/10.1007/s00428-023-03577-8" target="_blank">https://doi.org/10.1007/s00428-023-03577-8</a>
dc.identifier.otherCONVID_183656214
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/88004
dc.description.abstractTertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates located at sites of chronic inflammation and recognized as prognosticators in several cancers. We aimed to analyse the prognostic effect of TLSs in colorectal cancer (CRC) pulmonary metastases and primary tumours, with a comparison to the CD3+ and CD8+ cell density-based immune cell score (ICS). For TLS density and TLS maximum diameter analysis, 67 pulmonary metastases and 63 primary tumours were stained with haematoxylin and eosin. For ICS scoring and analysis, CD3 and CD8 immunohistochemistry was performed. Excellent interobserver agreement was achieved in all TLS measurements. Of all patients, 36 patients had low TLS density (< 0.222 follicles/mm) and 31 patients had high TLS density (≥ 0.222 follicles/mm) in the first resected pulmonary metastases. TLS density (adjusted HR 0.91, 0.48–1.73) or maximum diameter (adjusted HR 0.78, 0.40–1.51) did not have prognostic value in pulmonary metastases. In primary tumours, higher TLS density (adjusted HR 0.39, 0.18–0.87) and maximum diameter (adjusted HR 0.28, 0.11–0.73) were associated with lower mortality. In the pulmonary metastases, ICS had superior prognostic value to TLSs; however, TLSs and ICS were significantly associated. In conclusion, TLSs in CRC pulmonary metastases had no prognostic value but correlated with the ICS. TLSs in primary tumours associated with favourable prognosis.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesVirchows Archiv
dc.rightsCC BY 4.0
dc.subject.othertertiary lymphoid structures
dc.subject.otherpulmonary metastasis
dc.subject.othermicrosatellite stable colorectal cancer
dc.titleTertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202306214054
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineCell and Molecular Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange21-32
dc.relation.issn0945-6317
dc.relation.volume483
dc.type.versionpublishedVersion
dc.rights.copyright© 2023 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysoetäpesäkkeet
dc.subject.ysokasvaimet
dc.subject.ysopaksusuolisyöpä
dc.subject.ysokeuhkot
dc.subject.ysosyöpätaudit
dc.subject.ysoennusteet
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p2298
jyx.subject.urihttp://www.yso.fi/onto/yso/p2299
jyx.subject.urihttp://www.yso.fi/onto/yso/p5937
jyx.subject.urihttp://www.yso.fi/onto/yso/p3185
jyx.subject.urihttp://www.yso.fi/onto/yso/p678
jyx.subject.urihttp://www.yso.fi/onto/yso/p3297
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s00428-023-03577-8
jyx.fundinginformationOpen Access funding provided by University of Oulu including Oulu University Hospital. This study was funded by Instrumentarium Science Foundation (OH), Mary and Georg C. Ehrnrooth Foundation (OH) and Finnish State Research Funding (OH, J-P.M), Cancer Foundation Finland (J.P.V), J&A Erkko Foundation (J-P.M, TTS).
dc.type.okmA1


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