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dc.contributor.authorNokia, Miriam S.
dc.contributor.authorWaselius, Tomi
dc.contributor.authorPenttonen, Markku
dc.date.accessioned2023-06-06T09:25:52Z
dc.date.available2023-06-06T09:25:52Z
dc.date.issued2023
dc.identifier.citationNokia, M. S., Waselius, T., & Penttonen, M. (2023). CA3–CA1 long‐term potentiation occurs regardless of respiration and cardiac cycle phases in urethane‐anesthetized rats. <i>Hippocampus</i>, <i>33</i>(11), 1228-1232. <a href="https://doi.org/10.1002/hipo.23551" target="_blank">https://doi.org/10.1002/hipo.23551</a>
dc.identifier.otherCONVID_183338105
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/87468
dc.description.abstractBreathing and heartbeat synchronize to each other and to brain function and affect cognition in humans. However, it is not clear how cardiorespiratory rhythms modulate such basic processes as synaptic plasticity thought to underlie learning. Thus, we studied if respiration and cardiac cycle phases at burst stimulation onset affect hippocampal long-term potentiation (LTP) in the CA3–CA1 synapse in urethane-anesthetized adult male Sprague–Dawley rats. In a between-subjects design, we timed burst stimulation of the ventral hippocampal commissure (vHC) to systole or diastole either during expiration or inspiration and recorded responses throughout the hippocampus with a linear probe. As classical conditioning in humans seems to be most efficient at expiration-diastole, we also expected LTP to be most efficient if burst stimulation was targeted to expiration-diastole. However, LTP was induced equally in all four groups and respiration and cardiac cycle phase did not modulate CA1 responses to vHC stimulation overall. This could be perhaps because we bypassed all natural routes of external influences on the CA1 by directly stimulating the vHC. In the future, the effect of cardiorespiratory rhythms on synaptic plasticity could also be studied in awake state and in other parts of the hippocampal tri-synaptic loop.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesHippocampus
dc.rightsCC BY 4.0
dc.subject.otherbreathing
dc.subject.otherheartbeat
dc.subject.otherhippocampus
dc.subject.otherlearning
dc.subject.othermemory
dc.subject.otherplasticity
dc.titleCA3–CA1 long‐term potentiation occurs regardless of respiration and cardiac cycle phases in urethane‐anesthetized rats
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202306063538
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.contributor.oppiaineSchool of Wellbeingen
dc.contributor.oppiainePsychologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1228-1232
dc.relation.issn1050-9631
dc.relation.numberinseries11
dc.relation.volume33
dc.type.versionpublishedVersion
dc.rights.copyright© 2023 The Authors. Hippocampus published by Wiley Periodicals LLC.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber316966
dc.relation.grantnumber321522
dc.subject.ysooppiminen
dc.subject.ysomuisti (kognitio)
dc.subject.ysoneuroplastisuus
dc.subject.ysohippokampus
dc.subject.ysohengitys
dc.subject.ysosydän
dc.subject.ysoaivot
dc.subject.ysosyke
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p2945
jyx.subject.urihttp://www.yso.fi/onto/yso/p2607
jyx.subject.urihttp://www.yso.fi/onto/yso/p24786
jyx.subject.urihttp://www.yso.fi/onto/yso/p21117
jyx.subject.urihttp://www.yso.fi/onto/yso/p5640
jyx.subject.urihttp://www.yso.fi/onto/yso/p16731
jyx.subject.urihttp://www.yso.fi/onto/yso/p7040
jyx.subject.urihttp://www.yso.fi/onto/yso/p3751
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1002/hipo.23551
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundinginformationThis study was funded by the Academy of Finland grant no. 321522 to MSN and 316966 to MP.
dc.type.okmA1


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