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dc.contributor.authorPekkala, Satu
dc.date.accessioned2023-03-09T12:52:04Z
dc.date.available2023-03-09T12:52:04Z
dc.date.issued2023
dc.identifier.citationPekkala, S. (2023). Fecal Metagenomics and Metabolomics Identifying Microbial Signatures in Non-Alcoholic Fatty Liver Disease. <i>International Journal of Molecular Sciences</i>, <i>24</i>(5), 4855. <a href="https://doi.org/10.3390/ijms24054855" target="_blank">https://doi.org/10.3390/ijms24054855</a>
dc.identifier.otherCONVID_177170641
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/85949
dc.description.abstractThe frequency of non-alcoholic fatty liver disease (NAFLD) has intensified, creating diagnostic challenges and increasing the need for reliable non-invasive diagnostic tools. Due to the importance of the gut–liver axis in the progression of NAFLD, studies attempt to reveal microbial signatures in NAFLD, evaluate them as diagnostic biomarkers, and to predict disease progression. The gut microbiome affects human physiology by processing the ingested food into bioactive metabolites. These molecules can penetrate the portal vein and the liver to promote or prevent hepatic fat accumulation. Here, the findings of human fecal metagenomic and metabolomic studies relating to NAFLD are reviewed. The studies present mostly distinct, and even contradictory, findings regarding microbial metabolites and functional genes in NAFLD. The most abundantly reproducing microbial biomarkers include increased lipopolysaccharides and peptidoglycan biosynthesis, enhanced degradation of lysine, increased levels of branched chain amino acids, as well as altered lipid and carbohydrate metabolism. Among other causes, the discrepancies between the studies may be related to the obesity status of the patients and the severity of NAFLD. In none of the studies, except for one, was diet considered, although it is an important factor driving gut microbiota metabolism. Future studies should consider diet in these analyses.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofseriesInternational Journal of Molecular Sciences
dc.rightsCC BY 4.0
dc.subject.othergut microbiota
dc.subject.othermetabolomics
dc.subject.othermetagenomics
dc.subject.otherliver fat
dc.subject.otherNAFLD
dc.subject.otherdiet
dc.subject.othermetabolic pathways
dc.titleFecal Metagenomics and Metabolomics Identifying Microbial Signatures in Non-Alcoholic Fatty Liver Disease
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202303092106
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange4855
dc.relation.issn1661-6596
dc.relation.numberinseries5
dc.relation.volume24
dc.type.versionpublishedVersion
dc.rights.copyright© 2023 the Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber301824
dc.relation.grantnumber349264
dc.subject.ysosuolistomikrobisto
dc.subject.ysorasvamaksa
dc.subject.ysomaksa
dc.subject.ysoaineenvaihdunta
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p37925
jyx.subject.urihttp://www.yso.fi/onto/yso/p21481
jyx.subject.urihttp://www.yso.fi/onto/yso/p11264
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/ijms24054855
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramResearch profiles, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramProfilointi, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundinginformationThis study was supported by the Academy of Finland Profi5 (#301824) funding (Physical ACTivity and health during the human life-Span 2; PACTS2) to the University of Jyväskylä and by an Academy of Finland grant to S.P. (grant ID 349264)
dc.type.okmA1


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