Näytä suppeat kuvailutiedot

dc.contributor.authorWaselius, Tomi
dc.contributor.authorXu, Weiyong
dc.contributor.authorSparre, Julia Isabella
dc.contributor.authorPenttonen, Markku
dc.contributor.authorNokia, Miriam S.
dc.date.accessioned2022-02-18T11:34:11Z
dc.date.available2022-02-18T11:34:11Z
dc.date.issued2022
dc.identifier.citationWaselius, T., Xu, W., Sparre, J. I., Penttonen, M., & Nokia, M. S. (2022). ­Cardiac cycle and respiration phase affect responses to the conditioned stimulus in young adults trained in trace eyeblink conditioning. <i>Journal of Neurophysiology</i>, <i>127</i>(3), 767-775. <a href="https://doi.org/10.1152/jn.00298.2021" target="_blank">https://doi.org/10.1152/jn.00298.2021</a>
dc.identifier.otherCONVID_104202059
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/79846
dc.description.abstractRhythms of breathing and heartbeat are linked to each other as well as to rhythms of the brain. Our recent studies suggest that presenting the conditioned stimulus during expiration or during the diastolic phase of the cardiac cycle facilitates neural processing of that stimulus and improves learning an eyeblink classical conditioning task. To date, it has not been examined whether utilizing information from both respiration and cardiac cycle phases simultaneously allows even more efficient modulation of learning. Here we studied whether the timing of the conditioned stimulus to different cardiorespiratory rhythm phase combinations affects learning trace eyeblink conditioning in healthy young adults. The results were consistent with previous reports: Timing the conditioned stimulus to diastole during expiration was more beneficial for learning than timing it to systole during inspiration. Cardiac cycle phase seemed to explain most of this variation in learning at the behavioral level. Brain evoked potentials (N1) elicited by the conditioned stimulus and recorded using electroencephalogram were larger when the conditioned stimulus was presented to diastole during expiration than when it was presented to systole during inspiration. Breathing phase explained the variation in the N1 amplitude. To conclude, our findings suggest that non-invasive monitoring of bodily rhythms combined with closed-loop control of stimulation can be used to promote learning in humans. The next step will be to test if performance can also be improved in humans with compromised cognitive ability, such as in older people with memory impairments.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesJournal of Neurophysiology
dc.rightsIn Copyright
dc.subject.otherhengitys
dc.subject.othersydämen syke
dc.subject.otherherätevaste
dc.subject.otheroppiminen
dc.subject.otherbreathing
dc.subject.otherheartbeat
dc.subject.otherevent-related potential
dc.subject.otherlearning
dc.title­Cardiac cycle and respiration phase affect responses to the conditioned stimulus in young adults trained in trace eyeblink conditioning
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202202181573
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineKäyttäytymisen muutos, hyvinvointi ja terveys elämänkulussafi
dc.contributor.oppiaineAivojen muutokset elinkaaren aikanafi
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineSchool of Wellbeingen
dc.contributor.oppiaineBehaviour change, health, and well-being across the lifespanen
dc.contributor.oppiaineBrain changes across the life-spanen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange767-775
dc.relation.issn0022-3077
dc.relation.numberinseries3
dc.relation.volume127
dc.type.versionacceptedVersion
dc.rights.copyright© 2022, Journal of Neurophysiology
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber321522
dc.subject.ysosyke
dc.subject.ysooppiminen
dc.subject.ysohengitys
dc.subject.ysoehdollistuminen
dc.subject.ysopsykofysiologia
dc.subject.ysokognitiiviset prosessit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p3751
jyx.subject.urihttp://www.yso.fi/onto/yso/p2945
jyx.subject.urihttp://www.yso.fi/onto/yso/p5640
jyx.subject.urihttp://www.yso.fi/onto/yso/p2942
jyx.subject.urihttp://www.yso.fi/onto/yso/p7543
jyx.subject.urihttp://www.yso.fi/onto/yso/p5283
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1152/jn.00298.2021
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundinginformationThe work was supported by the Academy of Finland grant number 321522 to MSN.
dc.type.okmA1


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