Coinfection outcome in an opportunistic pathogen depends on the inter-strain interactions
Kinnula, H., Mappes, J., & Sundberg, L.-R. (2017). Coinfection outcome in an opportunistic pathogen depends on the inter-strain interactions. BMC Evolutionary Biology, 17, 77. https://doi.org/10.1186/s12862-017-0922-2
Julkaistu sarjassa
BMC Evolutionary BiologyPäivämäärä
2017Oppiaine
Ekologia ja evoluutiobiologiaSolu- ja molekyylibiologiaEcology and Evolutionary BiologyCell and Molecular BiologyTekijänoikeudet
© The Author(s). 2017. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License.
Background: In nature, organisms are commonly coinfected by two or more parasite strains, which has been
shown to influence disease virulence. Yet, the effects of coinfections of environmental opportunistic pathogens on
disease outcome are still poorly known, although as host-generalists they are highly likely to participate in
coinfections. We asked whether coinfection with conspecific opportunistic strains leads to changes in virulence, and
if these changes are associated with bacterial growth or interference competition. We infected zebra fish
(Danio rerio) with three geographically and/or temporally distant environmental opportunist Flavobacterium
columnare strains in single and in coinfection. Growth of the strains was studied in single and in co-cultures in
liquid medium, and interference competition (growth-inhibiting ability) on agar.
Results: The individual strains differed in their virulence, growth and ability for interference competition. Number of
coinfecting strains significantly influenced the virulence of infection, with three-strain coinfection differing from the
two-strain and single infections. Differences in virulence seemed to associate with the identity of the coinfecting
bacterial strains, and their pairwise interactions. This indicates that benefits of competitive ability (production of
growth-inhibiting compounds) for virulence are highest when multiple strains co-occur, whereas the high virulence
in coinfection may be independent from in vitro bacterial growth.
Conclusions: Intraspecific competition can lead to plastic increase in virulence, likely caused by faster utilization of
host resources stimulated by the competitive interactions between the strains. However, disease outcome depends
both on the characteristics of individual strains and their interactions. Our results highlight the importance of strain
interactions in disease dynamics in environments where various pathogen genotypes co-occur.
...
Julkaisija
BioMed CentralISSN Hae Julkaisufoorumista
1471-2148Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/26909508
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Lisenssi
Ellei muuten mainita, aineiston lisenssi on © The Author(s). 2017. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License.
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
The influence of infective dose, nutrient availability and coinfection on virulence of Flavobacterium columnare : implications of intensive aquaculture on opportunistic infections
Kinnula, Hanna (University of Jyväskylä, 2016)Ecological factors are known to affect disease dynamics and even lead to disease emergence. Especially in opportunistic, environmentally transmitted pathogens, the environment may significantly contribute to pathogen ... -
Effect of nutrients on competition between a virulent and a less virulent strain of the fish pathogen Flavobacterium columnare
Hämäläinen, Dorrit (2016)Patogeenit ovat haitallisia eliöitä, jotka tarvitsevat isäntää saadakseen tarvittavia ravinteita. Patogeenin haitallisuutta kutsutaan virulenssiksi, ja se on tärkeä osuus patogeeni-isäntä–suhteessa. Virulenssia säädellään ... -
Growth and competition of Flavobacterium columnare strains in two different nutrient levels
Nkembeng, Aloysius (2016)Human influence on the environment has led to changes in ecological factors which have greatly contributed to the emergence of different infectious diseases. The introduction of parasites in a new or changed environment ... -
Exploring evolutionary responses to increasing temperature in an environmental opportunistic pathogen
Ashrafi, Roghaieh (University of Jyväskylä, 2017) -
Genetic and environmental factors associated with the virulence of fish pathogen Flavobacterium columnare
Penttinen, Reetta (University of Jyväskylä, 2016)
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.