Hippocampal ripple-contingent training accelerates trace eyeblink conditioning and retards extinction in rabbits
Nokia, M., Penttonen, M., & Wikgren, J. (2010). Hippocampal ripple-contingent training accelerates trace eyeblink conditioning and retards extinction in rabbits. The Journal of Neuroscience, 30(34), 11486-11492. https://doi.org/10.1523/JNEUROSCI.2165-10.2010
Julkaistu sarjassa
The Journal of NeurosciencePäivämäärä
2010Oppiaine
PsykologiaMonitieteinen aivotutkimuskeskusHyvinvoinnin tutkimuksen yhteisöPsychologyCentre for Interdisciplinary Brain ResearchSchool of WellbeingTekijänoikeudet
© 2010 the Authors. Published by Society for Neuroscience. Published in this repository with the kind permission of the publisher.
There are at least two distinct oscillatory states of the hippocampus that are related to distinct behavioral patterns. Theta (4–12 Hz) oscillation has been suggested to indicate selective attention during which the animal concentrates on some features of the environment while suppressing reactivity to others. In contrast, sharp-wave ripples (∼200 Hz) can be seen in a state in which the hippocampus is at its most responsive to any kind of afferent stimulation. In addition, external stimulation tends to evoke and reset theta oscillation, the phase of which has been shown to modulate synaptic plasticity in the hippocampus. Theoretically, training on a hippocampus-dependent learning task contingent upon ripples could enhance learning rate due to elevated responsiveness and enhanced phase locking of the theta oscillation. We used a brain–computer interface to detect hippocampal ripples in rabbits to deliver trace eyeblink conditioning and extinction trials selectively contingent upon them. A yoked control group was trained regardless of their ongoing neural state. Ripple-contingent training expedited acquisition of the conditioned response early in training and evoked stronger theta-band phase locking to the conditioned stimulus. Surprisingly, ripple-contingent training also resulted in slower extinction in well trained animals. We suggest that the ongoing oscillatory activity in the hippocampus determines the extent to which a stimulus can induce a phase reset of the theta oscillation, which in turn is the determining factor of learning rate in trace eyeblink conditioning.
...
Julkaisija
Society for NeuroscienceISSN Hae Julkaisufoorumista
0270-6474Asiasanat
Alkuperäislähde
http://www.jneurosci.org/cgi/content/abstract/30/34/11486?etocJulkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/19579730
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Lisenssi
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
Hippocampal theta activity is selectively associated with contingency detection but not discrimination in rabbit discrimination-reversal eyeblink conditioning
Nokia, Miriam; Wikgren, Jan (Wiley, 2010)The relative power of the hippocampal theta-band (∼6 Hz) activity (theta ratio) is thought to reflect a distinct neural state and has been shown to affect learning rate in classical eyeblink conditioning in rabbits. We ... -
Trace eyeblink conditioning and extinction contingent to hippocampal ripples in rabbits
Raussi, Pekka (2014) -
The role of the hippocampal theta activity in classical eyeblink conditioning in rabbits
Nokia, Miriam (University of Jyväskylä, 2009) -
Hippocampal theta phase-contingent memory retrieval in delay and trace eyeblink conditioning
Waselius, Tomi; Pöllänen, Eveliina; Wikgren, Jan; Penttonen, Markku; Nokia, Miriam (Elsevier BV, 2017)Hippocampal theta oscillations (3–12 Hz) play a prominent role in learning. It has been suggested that encoding and retrieval of memories are supported by different phases of the theta cycle. Our previous study on trace ... -
Hippocampal theta-band activity and trace eyeblink conditioning in rabbits
Nokia, Miriam; Penttonen, Markku; Korhonen, Tapani; Wikgren, Jan (APA, 2009)The authors examined the relationship between hippocampal theta activity and trace eyeblink conditioning. Hippocampal electrophysiological local field potentials were recorded before, during, and after conditioning or ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.