Intramuscular sex steroid hormones are associated with skeletal muscle strength and power in women with different hormonal status
dc.contributor.author | Pöllänen, Eija | |
dc.contributor.author | Kangas, Reeta | |
dc.contributor.author | Horttanainen, Mia | |
dc.contributor.author | Niskala, Paula | |
dc.contributor.author | Kaprio, Jaakko | |
dc.contributor.author | Butler-Browne, Gillian | |
dc.contributor.author | Mouly, Vincent | |
dc.contributor.author | Sipilä, Sarianna | |
dc.contributor.author | Kovanen, Vuokko | |
dc.date.accessioned | 2015-04-29T04:55:20Z | |
dc.date.available | 2015-04-29T04:55:20Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Pöllänen, E., Kangas, R., Horttanainen, M., Niskala, P., Kaprio, J., Butler-Browne, G., Mouly, V., Sipilä, S., & Kovanen, V. (2015). Intramuscular sex steroid hormones are associated with skeletal muscle strength and power in women with different hormonal status. <i>Aging Cell</i>, <i>14</i>(2), 236-248. <a href="https://doi.org/10.1111/acel.12309" target="_blank">https://doi.org/10.1111/acel.12309</a> | |
dc.identifier.other | CONVID_24531868 | |
dc.identifier.other | TUTKAID_65128 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/45737 | |
dc.description.abstract | Estrogen (E2)-responsive peripheral tissues, such as skeletal muscle, may suffer from hormone deficiency after menopause potentially contributing to the aging of muscle. However, recently E2 was shown to be synthesized by muscle and its systemic and intramuscular hormone levels are unequal. The objective of the study was to examine the association between intramuscular steroid hormones and muscle characteristics in premenopausal women (n = 8) and in postmenopausal monozygotic twin sister pairs (n = 16 co-twins from eight pairs) discordant for the use of E2-based hormone replacement. Isometric skeletal muscle strength was assessed by measuring knee extension strength. Explosive lower body muscle power was assessed as vertical jump height. Due to sequential nature of enzymatic conversion of biologically inactive dehydroepiandrosterone (DHEA) to testosterone (T) and subsequently to E2 or dihydrotestosterone (DHT), separate linear regression models were used to estimate the association of each hormone with muscle characteristics. Intramuscular E2, T, DHT, and DHEA proved to be significant, independent predictors of strength and power explaining 59–64% of the variation in knee extension strength and 80–83% of the variation of vertical jumping height in women (P < 0.005 for all models). The models were adjusted for age, systemic E2, and total body fat mass. The statistics used took into account the lack of statistical independence of twin sisters. Furthermore, muscle cells were shown to take up and actively synthesize hormones. Present study suggests intramuscular sex steroids to associate with strength and power regulation in female muscle providing novel insight to the field of muscle aging. | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell Publishing Ltd.; Anatomical Society | |
dc.relation.ispartofseries | Aging Cell | |
dc.subject.other | intracrine organ | |
dc.subject.other | steroidogenesis | |
dc.subject.other | muscle performance | |
dc.subject.other | local hormone synthesis | |
dc.subject.other | muscle steroids | |
dc.title | Intramuscular sex steroid hormones are associated with skeletal muscle strength and power in women with different hormonal status | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201503171483 | |
dc.contributor.laitos | Terveystieteiden laitos | fi |
dc.contributor.laitos | Department of Health Sciences | en |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Gerontologian tutkimuskeskus | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.contributor.oppiaine | Gerontology Research Center | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2015-03-17T16:30:04Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 236–248 | |
dc.relation.issn | 1474-9718 | |
dc.relation.numberinseries | 2 | |
dc.relation.volume | 14 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |
dc.rights.accesslevel | openAccess | fi |
dc.rights.url | http://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1111/acel.12309 | |
dc.type.okm | A1 |
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Ellei muuten mainita, aineiston lisenssi on © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.