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dc.contributor.authorHealy, Darren R.
dc.contributor.authorZarei, Iman
dc.contributor.authorMikkonen, Santtu
dc.contributor.authorSoininen, Sonja
dc.contributor.authorViitasalo, Anna
dc.contributor.authorHaapala, Eero A.
dc.contributor.authorAuriola, Seppo
dc.contributor.authorHanhineva, Kati
dc.contributor.authorKolehmainen, Marjukka
dc.contributor.authorLakka, Timo A.
dc.date.accessioned2024-08-14T09:39:39Z
dc.date.available2024-08-14T09:39:39Z
dc.date.issued2024
dc.identifier.citationHealy, D. R., Zarei, I., Mikkonen, S., Soininen, S., Viitasalo, A., Haapala, E. A., Auriola, S., Hanhineva, K., Kolehmainen, M., & Lakka, T. A. (2024). Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence. <i>Communications Biology</i>, <i>7</i>(1), Article 890. <a href="https://doi.org/10.1038/s42003-024-06146-0" target="_blank">https://doi.org/10.1038/s42003-024-06146-0</a>
dc.identifier.otherCONVID_233329587
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/96592
dc.description.abstractEnvironmental and lifestyle factors, including air pollution, impaired diet, and low physical activity, have been associated with cardiometabolic risk factors in childhood and adolescence. However, environmental and lifestyle exposures do not exert their physiological effects in isolation. This study investigated associations between an exposome score to measure the impact of multiple exposures, including diet, physical activity, sleep duration, air pollution, and socioeconomic status, and serum metabolites measured using LC-MS and NMR, compared to the individual components of the score. A general population of 504 children aged 6-9 years at baseline was followed up for eight years. Data were analysed with linear mixed-effects models using the R software. The exposome score was associated with 31 metabolites, of which 12 metabolites were not associated with any individual exposure category. These findings highlight the value of a composite score to predict metabolic changes associated with multiple environmental and lifestyle exposures since childhood. A composite exposome score was associated with 31 serum metabolites measured by LC-MS and NMR in children followed to adolescence. Altogether, 12 of these associations were unique to the exposome score, with several findings modified by adiposity.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesCommunications Biology
dc.rightsCC BY 4.0
dc.titleLongitudinal associations of an exposome score with serum metabolites from childhood to adolescence
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202408145475
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2399-3642
dc.relation.numberinseries1
dc.relation.volume7
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2024
dc.rights.accesslevelopenAccessfi
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysoelintavat
dc.subject.ysoaineenvaihduntatuotteet
dc.subject.ysolapset (ikäryhmät)
dc.subject.ysoseerumi
dc.subject.ysoriskitekijät
dc.subject.ysososioekonominen asema
dc.subject.ysoympäristötekijät
dc.subject.ysoruokavaliot
dc.subject.ysonuoret
dc.subject.ysosydän- ja verisuonitaudit
dc.subject.ysopitkittäistutkimus
dc.subject.ysoilmansaasteet
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p5530
jyx.subject.urihttp://www.yso.fi/onto/yso/p24583
jyx.subject.urihttp://www.yso.fi/onto/yso/p4354
jyx.subject.urihttp://www.yso.fi/onto/yso/p4127
jyx.subject.urihttp://www.yso.fi/onto/yso/p13277
jyx.subject.urihttp://www.yso.fi/onto/yso/p2137
jyx.subject.urihttp://www.yso.fi/onto/yso/p6194
jyx.subject.urihttp://www.yso.fi/onto/yso/p3790
jyx.subject.urihttp://www.yso.fi/onto/yso/p11617
jyx.subject.urihttp://www.yso.fi/onto/yso/p9886
jyx.subject.urihttp://www.yso.fi/onto/yso/p14610
jyx.subject.urihttp://www.yso.fi/onto/yso/p28397
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s42003-024-06146-0
jyx.fundinginformationThe PANIC Study has received funding from Ministry of Education and Culture of Finland, Ministry of Social Affairs and Health of Finland, Academy of Finland, Research Committee of the Kuopio University Hospital Catchment Area (State Research Funding), Finnish Innovation Fund Sitra, Social Insurance Institution of Finland, Finnish Cultural Foundation, Foundation for Pediatric Research, Diabetes Research Foundation in Finland, Finnish Foundation for Cardiovascular Research, Juho Vainio Foundation, Paavo Nurmi Foundation, Yrjö Jahnsson Foundation, and the city of Kuopio. Moreover, this project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 874739.
dc.type.okmA1


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