dc.contributor.author | Healy, Darren R. | |
dc.contributor.author | Zarei, Iman | |
dc.contributor.author | Mikkonen, Santtu | |
dc.contributor.author | Soininen, Sonja | |
dc.contributor.author | Viitasalo, Anna | |
dc.contributor.author | Haapala, Eero A. | |
dc.contributor.author | Auriola, Seppo | |
dc.contributor.author | Hanhineva, Kati | |
dc.contributor.author | Kolehmainen, Marjukka | |
dc.contributor.author | Lakka, Timo A. | |
dc.date.accessioned | 2024-08-14T09:39:39Z | |
dc.date.available | 2024-08-14T09:39:39Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Healy, D. R., Zarei, I., Mikkonen, S., Soininen, S., Viitasalo, A., Haapala, E. A., Auriola, S., Hanhineva, K., Kolehmainen, M., & Lakka, T. A. (2024). Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence. <i>Communications Biology</i>, <i>7</i>(1), Article 890. <a href="https://doi.org/10.1038/s42003-024-06146-0" target="_blank">https://doi.org/10.1038/s42003-024-06146-0</a> | |
dc.identifier.other | CONVID_233329587 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/96592 | |
dc.description.abstract | Environmental and lifestyle factors, including air pollution, impaired diet, and low physical activity, have been associated with cardiometabolic risk factors in childhood and adolescence. However, environmental and lifestyle exposures do not exert their physiological effects in isolation. This study investigated associations between an exposome score to measure the impact of multiple exposures, including diet, physical activity, sleep duration, air pollution, and socioeconomic status, and serum metabolites measured using LC-MS and NMR, compared to the individual components of the score. A general population of 504 children aged 6-9 years at baseline was followed up for eight years. Data were analysed with linear mixed-effects models using the R software. The exposome score was associated with 31 metabolites, of which 12 metabolites were not associated with any individual exposure category. These findings highlight the value of a composite score to predict metabolic changes associated with multiple environmental and lifestyle exposures since childhood.
A composite exposome score was associated with 31 serum metabolites measured by LC-MS and NMR in children followed to adolescence. Altogether, 12 of these associations were unique to the exposome score, with several findings modified by adiposity. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.relation.ispartofseries | Communications Biology | |
dc.rights | CC BY 4.0 | |
dc.title | Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202408145475 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.relation.issn | 2399-3642 | |
dc.relation.numberinseries | 1 | |
dc.relation.volume | 7 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © The Author(s) 2024 | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | fyysinen aktiivisuus | |
dc.subject.yso | elintavat | |
dc.subject.yso | aineenvaihduntatuotteet | |
dc.subject.yso | lapset (ikäryhmät) | |
dc.subject.yso | seerumi | |
dc.subject.yso | riskitekijät | |
dc.subject.yso | sosioekonominen asema | |
dc.subject.yso | ympäristötekijät | |
dc.subject.yso | ruokavaliot | |
dc.subject.yso | nuoret | |
dc.subject.yso | sydän- ja verisuonitaudit | |
dc.subject.yso | pitkittäistutkimus | |
dc.subject.yso | ilmansaasteet | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p23102 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5530 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p24583 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p4354 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p4127 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p13277 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p2137 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p6194 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p3790 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p11617 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p9886 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p14610 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p28397 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1038/s42003-024-06146-0 | |
jyx.fundinginformation | The PANIC Study has received funding from Ministry of Education and Culture of Finland, Ministry of Social Affairs and Health of Finland, Academy of Finland, Research Committee of the Kuopio University Hospital Catchment Area (State Research Funding), Finnish Innovation Fund Sitra, Social Insurance Institution of Finland, Finnish Cultural Foundation, Foundation for Pediatric Research, Diabetes Research Foundation in Finland, Finnish Foundation for Cardiovascular Research, Juho Vainio Foundation, Paavo Nurmi Foundation, Yrjö Jahnsson Foundation, and the city of Kuopio. Moreover, this project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 874739. | |
dc.type.okm | A1 | |