Effects of exercise on whole‐blood transcriptome profile in children with overweight/obesity
Altmäe, S., Plaza‐Florido, A., Esteban, F. J., Anguita‐Ruiz, A., Krjutškov, K., Katayama, S., Einarsdottir, E., Kere, J., Radom‐Aizik, S., & Ortega, F. B. (2024). Effects of exercise on whole‐blood transcriptome profile in children with overweight/obesity. American Journal of Human Biology, 36(2), Article e23983. https://doi.org/10.1002/ajhb.23983
Julkaistu sarjassa
American Journal of Human BiologyTekijät
Päivämäärä
2024Tekijänoikeudet
© 2023 the Authors
Background
The current knowledge about the molecular mechanisms underlying the health benefits of exercise is still limited, especially in childhood. We set out to investigate the effects of a 20-week exercise intervention on whole-blood transcriptome profile (RNA-seq) in children with overweight/obesity.
Methods
Twenty-four children (10.21 ± 1.33 years, 46% girls) with overweight/obesity, were randomized to either a 20-week exercise program (intervention group; n = 10), or to a no-exercise control group (n = 14). Whole-blood transcriptome profile was analyzed using RNA-seq by STRT technique with GlobinLock technology.
Results
Following the 20-week exercise intervention program, 161 genes were differentially expressed between the exercise and the control groups among boys, and 121 genes among girls (p-value <0.05), while after multiple correction, no significant difference between exercise and control groups persisted in gene expression profiles (FDR >0.05). Genes enriched in GO processes and molecular pathways showed different immune response in boys (antigen processing and presentation, infections, and T cell receptor complex) and in girls (Fc epsilon RI signaling pathway) (FDR <0.05).
Conclusion
These results suggest that 20-week exercise intervention program alters the molecular pathways involved in immune processes in children with overweight/obesity.
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Julkaisija
WileyISSN Hae Julkaisufoorumista
1042-0533Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/189068257
Metadata
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Lisätietoja rahoituksesta
The project was funded by the Spanish Ministry of Economy and Competitiveness (Reference DEP2013-47540 and DEP2016-79512-R). Signe Altmäe is funded by MCIN/AEI/10.13039/501100011033 and ERFD A way of making Europe Grant PID2021-127280OB-I00 (Endo-Map). Francisco J. Esteban is supported by the Junta de Andalucía [BIO-302; US-1254251]; the University of Jaén [PAIUJA-EI_CTS02]. Abel Plaza-Florido is supported by the Spanish Ministry of Education, Culture and Sport (FPU16/02760). Abel Plaza-Florido and Shlomit Radom-Aizik contribution was funded in part by NIH grant #: U01TR002004 (REACH project). Additional support was obtained from Unit of Excellence on Exercise and Health (UCEES) and EXERNET Research Network on Exercise and Health in Special Populations (DEP2005-00046/ACTI). This study has been partially funded by the University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), and by the Junta deAndalucía, Consejería de Conocimiento, Investigacion y Universidades and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR. Work at the Juha Kere laboratory was supported by Sigrid Jusélius Foundation and Jane and Aatos Erkko Foundation (Finland). Funding for open access charge: Universidad de Granada/CBUA. ...Lisenssi
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