Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity
Gil‐Cosano, J. J., Gracia‐Marco, L., Ubago‐Guisado, E., Migueles, J. H., Courteix, D., Labayen, I., Plaza‐Florido, A., Molina‐García, P., Dutheil, F., & Ortega, F. B. (2022). Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity. Acta Paediatrica, 111(10), 1966-1973. https://doi.org/10.1111/apa.16456
Julkaistu sarjassa
Acta PaediatricaTekijät
Päivämäärä
2022Tekijänoikeudet
© 2022 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica
Aim
Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the relationships of resting leptin and adiponectin with bone parameters and whether high muscular fitness levels affect these relationships in children with overweight or obesity.
Methods
This cross-sectional study took part from 2014 to 2016 in Granada, Spain. Participants were recruited from University Hospitals, and we also used advertisements in local media and school contacts in the city. Adipokines were analysed in plasma. Muscular fitness was assessed by one repetition maximum in bench and leg press tests. Dual-energy X-ray absorptiometry was used to measure bone parameters.
Results
We included 84 children (10.0 ± 1.2y; 63% boys) in this analysis. Leptin was negatively associated with lumbar spine bone mineral content (β = −0.162, p = 0.053). No significant interaction was found for muscular fitness. Simple slope estimates suggested that children performing more than 133.3 kg in leg press test ameliorated the negative association between leptin and lumbar spine bone mineral content.
Conclusion
Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity. A high muscular fitness at the lower body could counteract this association.
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Julkaisija
WileyISSN Hae Julkaisufoorumista
0803-5253Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/193457690
Metadata
Näytä kaikki kuvailutiedotKokoelmat
- Liikuntatieteiden tiedekunta [2920]
Lisätietoja rahoituksesta
This study was mainly supported by grants from the Spanish Ministry of Economy and Competitiveness (DEP2013-47540, DEP2016-79512-R, DEP2017-91544-EXP and RYC-2011-09011), European Regional Development Fund (ERDF) of the European Commission (No 667302) and the Alicia Koplowitz Foundation. Additional funding was obtained from the Andalusian Operational Programme supported with ERDF (FEDER in Spanish, B-CTS-355-UGR18). Additional support was obtained from University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence, Unit of Excellence on Exercise and Health, the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (SOMM17/6107/UGR); the EXERNET Research Network on Exercise and Health in Special populations (DEP2005-00046/ACTI); and the HL-PIVOT network - Healthy Living for Pandemic Event Protection. Funding for open access charge: Universidad de Granada / CBUA. ...Lisenssi
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