Mechanochemical Difluoromethylations of Alcohols
Abstract
Difluoromethyl ethers are formed through mechanochemical reactions of alcohols with difluorocarbene in a mixer mill. The protocol could be applied to primary, secondary, and tertiary alcohols, yielding the corresponding products in excellent yields (up to 99%) after 1 h reaction time at room temperature. The transformations proceeded under solvent-free reaction conditions, followed by product purification by filtration, which drastically reduced the amount of waste generated during the process.
Main Authors
Format
Articles
Research article
Published
2023
Series
Subjects
Publication in research information system
Publisher
Chinese Chemical Society
The permanent address of the publication
https://urn.fi/URN:NBN:fi:jyu-202308244740Use this for linking
Review status
Peer reviewed
ISSN
2096-5745
DOI
https://doi.org/10.31635/ccschem.023.202302783
Language
English
Published in
CCS chemistry
Citation
- van Bonn, P., Ke, J., Weike, C., Ward, J. S., Rissanen, K., & Bolm, C. (2023). Mechanochemical Difluoromethylations of Alcohols. CCS chemistry, 5(8), 1737-1744. https://doi.org/10.31635/ccschem.023.202302783
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Additional information about funding
This research was made possible by the generous support of the Rhine-Westphalia Technical University of Aachen (RWTH Aachen University). We also acknowledge the Alexander von Humboldt Foundation for support of K. R. (AvH research award).
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