Mechanochemical Difluoromethylations of Alcohols
van Bonn, P., Ke, J., Weike, C., Ward, J. S., Rissanen, K., & Bolm, C. (2023). Mechanochemical Difluoromethylations of Alcohols. CCS chemistry, 5(8), 1737-1744. https://doi.org/10.31635/ccschem.023.202302783
Julkaistu sarjassa
CCS chemistryPäivämäärä
2023Tekijänoikeudet
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Difluoromethyl ethers are formed through mechanochemical reactions of alcohols with difluorocarbene in a mixer mill. The protocol could be applied to primary, secondary, and tertiary alcohols, yielding the corresponding products in excellent yields (up to 99%) after 1 h reaction time at room temperature. The transformations proceeded under solvent-free reaction conditions, followed by product purification by filtration, which drastically reduced the amount of waste generated during the process.
Julkaisija
Chinese Chemical SocietyISSN Hae Julkaisufoorumista
2096-5745Asiasanat
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https://converis.jyu.fi/converis/portal/detail/Publication/184109461
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This research was made possible by the generous support of the Rhine-Westphalia Technical University of Aachen (RWTH Aachen University). We also acknowledge the Alexander von Humboldt Foundation for support of K. R. (AvH research award).Lisenssi
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