Gut microbiome and atrial fibrillation : results from a large population-based study
Palmu, J., Börschel, C. S., Ortega-Alonso, A., Markó, L., Inouye, M., Jousilahti, P., Salido, R. A., Sanders, K., Brennan, C., Humphrey, G. C., Sanders, J. G., Gutmann, F., Linz, D., Salomaa, V., Havulinna, A. S., Forslund, S. K., Knight, R., Lahti, L., Niiranen, T., & Schnabel, R. B. (2023). Gut microbiome and atrial fibrillation : results from a large population-based study. EBioMedicine, 91, Article 104583. https://doi.org/10.1016/j.ebiom.2023.104583
Julkaistu sarjassa
EBioMedicineTekijät
Päivämäärä
2023Tekijänoikeudet
© 2023 The Author(s). Published by Elsevier B.V.
Background
Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown.
Methods
We examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case–control cohort of 138 individuals in Hamburg, Germany.
Findings
Multivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 539) over a median follow-up of 15 years was associated with eight microbial genera with false discovery rate (FDR)-corrected P < 0.05. Both prevalent and incident AF were associated with the genera Enorma and Bifidobacterium (FDR-corrected P < 0.001). AF was not significantly associated with bacterial diversity measures. Seventy-five percent of top genera (Enorma, Paraprevotella, Odoribacter, Collinsella, Barnesiella, Alistipes) in Cox regression analyses showed a consistent direction of shifted abundance in an independent AF case–control cohort that was used for replication.
Interpretation
Our findings establish the basis for the use of microbiome profiles in AF risk prediction. However, extensive research is still warranted before microbiome sequencing can be used for prevention and targeted treatment of AF.
Funding
This study was funded by European Research Council, German Ministry of Research and Education, Academy of Finland, Finnish Medical Foundation, and the Finnish Foundation for Cardiovascular Research, the Emil Aaltonen Foundation, and the Paavo Nurmi Foundation.
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Julkaisija
Elsevier BVISSN Hae Julkaisufoorumista
2352-3964Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/182960828
Metadata
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Lisätietoja rahoituksesta
RBS has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme under the grant agreement No 648131, from the European Union’s Horizon 2020 research and innovation programme under the grant agreement No 847770 (AFFECT-EU) and German Center for Cardiovascular Research (DZHK e.V.) (81Z1710103); German Ministry of Research and Education (BMBF 01ZX1408A) and ERACoSysMed3 (031L0239). ASH has received funding from the Academy of Finland (321356). TN has received funding from the Academy of Finland (321351), the Emil Aaltonen Foundation, and Finnish Medical Foundation, and the Finnish Foundation for Cardiovascular Research. LL has received funding from the Academy of Finland (295741). VS was supported by the Finnish Foundation for Cardiovascular research. JP was supported by the Paavo Nurmi Foundation. SKF has received funding from the German Center for Cardiovascular Research (DZHK e.V., Standort Berlin MDC) (81Z0100113) and the German Research Foundation (DFG, SFB1470).![showless](/themes/JYX2//images/showless.png)
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