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dc.contributor.authorCossin-Sevrin, Nina
dc.contributor.authorHsu, Bin-Yan
dc.contributor.authorMarciau, Coline
dc.contributor.authorViblanc, Vincent A.
dc.contributor.authorRuuskanen, Suvi
dc.contributor.authorStier, Antoine
dc.date.accessioned2022-09-29T11:01:55Z
dc.date.available2022-09-29T11:01:55Z
dc.date.issued2022
dc.identifier.citationCossin-Sevrin, N., Hsu, B.-Y., Marciau, C., Viblanc, V. A., Ruuskanen, S., & Stier, A. (2022). Developmental plasticity of mitochondrial aerobic metabolism, growth and survival by prenatal glucocorticoids and thyroid hormones : an experimental test in wild great tits. <i>Journal of Experimental Biology</i>, <i>225</i>(9), Article jeb243414. <a href="https://doi.org/10.1242/jeb.243414" target="_blank">https://doi.org/10.1242/jeb.243414</a>
dc.identifier.otherCONVID_118846791
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/83383
dc.description.abstractDevelopmental plasticity is partly mediated by transgenerational effects, including those mediated by the maternal endocrine system. Glucocorticoid and thyroid hormones may play central roles in developmental programming through their action on metabolism and growth. However, the mechanisms by which they affect growth and development remain understudied. One hypothesis is that maternal hormones directly affect the production and availability of energy-carrying molecules (e.g. ATP) by their action on mitochondrial function. To test this hypothesis, we experimentally increased glucocorticoid and thyroid hormones in wild great tit eggs (Parus major) to investigate their impact on offspring mitochondrial aerobic metabolism (measured in blood cells), and subsequent growth and survival. We show that prenatal glucocorticoid supplementation affected offspring cellular aerobic metabolism by decreasing mitochondrial density, maximal mitochondrial respiration and oxidative phosphorylation, while increasing the proportion of the maximum capacity being used under endogenous conditions. Prenatal glucocorticoid supplementation only had mild effects on offspring body mass, size and condition during the rearing period, but led to a sex-specific (females only) decrease in body mass a few months after fledging. Contrary to our expectations, thyroid hormones supplementation did not affect offspring growth or mitochondrial metabolism. Recapture probabilities as juveniles or adults were not significantly affected by prenatal hormonal treatments. Our results demonstrate that prenatal glucocorticoids can affect post-natal mitochondrial density and aerobic metabolism. The weak effects on growth and apparent survival suggest that nestlings were mostly able to compensate for the transient decrease in mitochondrial aerobic metabolism induced by prenatal glucocorticoids.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherThe Company of Biologists
dc.relation.ispartofseriesJournal of Experimental Biology
dc.rightsIn Copyright
dc.subject.othercellular metabolism
dc.subject.othercorticosterone
dc.subject.otherprenatal programming
dc.subject.otheravian development
dc.subject.otherthyroid hormones
dc.subject.otherParus major
dc.titleDevelopmental plasticity of mitochondrial aerobic metabolism, growth and survival by prenatal glucocorticoids and thyroid hormones : an experimental test in wild great tits
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202209294736
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn0022-0949
dc.relation.numberinseries9
dc.relation.volume225
dc.type.versionacceptedVersion
dc.rights.copyright© 2022. Published by The Company of Biologists Ltd.
dc.rights.accesslevelembargoedAccessfi
dc.subject.ysotalitiainen
dc.subject.ysokortikosteroni
dc.subject.ysoaineenvaihdunta
dc.subject.ysohormonaaliset tekijät
dc.subject.ysolinnut
dc.subject.ysosolufysiologia
dc.subject.ysosoluhengitys
dc.subject.ysokehitysbiologia
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p12931
jyx.subject.urihttp://www.yso.fi/onto/yso/p23119
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
jyx.subject.urihttp://www.yso.fi/onto/yso/p21658
jyx.subject.urihttp://www.yso.fi/onto/yso/p3363
jyx.subject.urihttp://www.yso.fi/onto/yso/p25367
jyx.subject.urihttp://www.yso.fi/onto/yso/p24868
jyx.subject.urihttp://www.yso.fi/onto/yso/p18588
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1242/jeb.243414
jyx.fundinginformationFunder(s): Horizon 2020 Framework Programme, Award Id(s): 894963 Funder(s): Academy of Finland, Award Id(s): 286278


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