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dc.contributor.authorKankaanpää, Anna
dc.contributor.authorTolvanen, Asko
dc.contributor.authorSaikkonen, Pirkko
dc.contributor.authorHeikkinen, Aino
dc.contributor.authorLaakkonen, Eija K
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorOllikainen, Miina
dc.contributor.authorSillanpää, Elina
dc.date.accessioned2022-08-25T11:28:09Z
dc.date.available2022-08-25T11:28:09Z
dc.date.issued2022
dc.identifier.citationKankaanpää, A., Tolvanen, A., Saikkonen, P., Heikkinen, A., Laakkonen, E. K., Kaprio, J., Ollikainen, M., & Sillanpää, E. (2022). Do Epigenetic Clocks Provide Explanations for Sex Differences in Life Span? : A Cross-Sectional Twin Study. <i>Journals of Gerontology Series A : Biological Sciences and Medical Sciences</i>, <i>77</i>(9), 1898-1906. <a href="https://doi.org/10.1093/gerona/glab337" target="_blank">https://doi.org/10.1093/gerona/glab337</a>
dc.identifier.otherCONVID_101840729
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/82830
dc.description.abstractBackground The sex gap in life expectancy has been narrowing in Finland over the past four to five decades; however, on average, women still live longer than men. Epigenetic clocks are markers for biological aging that predict lifespan. In this study, we examined the mediating role of lifestyle factors on the association between sex and biological aging in younger and older adults. Methods Our sample consists of younger and older twins (21‒42-y, n = 1477; 50‒76-y, n = 763) including 151 complete younger opposite-sex twin pairs (21‒30-y). Blood-based DNA methylation (DNAm) was used to compute epigenetic age acceleration by four epigenetic clocks as a measure of biological aging. Path modelling was used to study whether the association between sex and biological aging is mediated through lifestyle-related factors, i.e. education, body mass index, smoking, alcohol use, and physical activity. Results In comparison to women, men were biologically older and, in general, they had unhealthier life habits. The effect of sex on biological aging was partly mediated by body mass index and, in older twins, by smoking. Sex was directly associated with biological aging and the association was stronger in older twins. Conclusions Previously reported sex differences in lifespan are also evident in biological aging. Declining smoking prevalence among men is a plausible explanation for the narrowing of the difference in life expectancy between the sexes. Data generated by the epigenetic clocks may help in estimating the effects of lifestyle and environmental factors on aging and in predicting aging in future generations.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.relation.ispartofseriesJournals of Gerontology Series A : Biological Sciences and Medical Sciences
dc.rightsCC BY 4.0
dc.subject.otherDNA methylation
dc.subject.othersex gap
dc.subject.otherlifestyle
dc.subject.otherlifespan
dc.subject.otherbiological age
dc.titleDo Epigenetic Clocks Provide Explanations for Sex Differences in Life Span? : A Cross-Sectional Twin Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202208254362
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1898-1906
dc.relation.issn1079-5006
dc.relation.numberinseries9
dc.relation.volume77
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber202100426
dc.subject.ysosukupuolierot
dc.subject.ysoelinikä
dc.subject.ysoDNA-metylaatio
dc.subject.ysoikääntyminen
dc.subject.ysoepigenetiikka
dc.subject.ysoelintavat
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5290
jyx.subject.urihttp://www.yso.fi/onto/yso/p1227
jyx.subject.urihttp://www.yso.fi/onto/yso/p38350
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p24631
jyx.subject.urihttp://www.yso.fi/onto/yso/p5530
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1093/gerona/glab337
dc.relation.funderJuho Vainio Foundationen
dc.relation.funderJuho Vainion Säätiöfi
jyx.fundingprogramFoundationen
jyx.fundingprogramSäätiöfi
jyx.fundinginformationThis work was supported by the Academy of Finland (213506, 265240, 263278, 312073 to JK, and 297908 to MO), EC FP5 GenomEUtwin (JK), National Institutes of Health/National Heart, Lung, and Blood Institute (grant HL104125), EC MC ITN Project EPITRAIN (JK and MO), the University of Helsinki Research Funds (MO), Sigrid Juselius Foundation (JK and MO), Yrjö Jahnsson Foundation (6868), and Juho Vainio Foundation (ES)
dc.type.okmA1


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