dc.contributor.author | Kankaanpää, Anna | |
dc.contributor.author | Tolvanen, Asko | |
dc.contributor.author | Saikkonen, Pirkko | |
dc.contributor.author | Heikkinen, Aino | |
dc.contributor.author | Laakkonen, Eija K | |
dc.contributor.author | Kaprio, Jaakko | |
dc.contributor.author | Ollikainen, Miina | |
dc.contributor.author | Sillanpää, Elina | |
dc.date.accessioned | 2022-08-25T11:28:09Z | |
dc.date.available | 2022-08-25T11:28:09Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Kankaanpää, A., Tolvanen, A., Saikkonen, P., Heikkinen, A., Laakkonen, E. K., Kaprio, J., Ollikainen, M., & Sillanpää, E. (2022). Do Epigenetic Clocks Provide Explanations for Sex Differences in Life Span? : A Cross-Sectional Twin Study. <i>Journals of Gerontology Series A : Biological Sciences and Medical Sciences</i>, <i>77</i>(9), 1898-1906. <a href="https://doi.org/10.1093/gerona/glab337" target="_blank">https://doi.org/10.1093/gerona/glab337</a> | |
dc.identifier.other | CONVID_101840729 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/82830 | |
dc.description.abstract | Background
The sex gap in life expectancy has been narrowing in Finland over the past four to five decades; however, on average, women still live longer than men. Epigenetic clocks are markers for biological aging that predict lifespan. In this study, we examined the mediating role of lifestyle factors on the association between sex and biological aging in younger and older adults.
Methods
Our sample consists of younger and older twins (21‒42-y, n = 1477; 50‒76-y, n = 763) including 151 complete younger opposite-sex twin pairs (21‒30-y). Blood-based DNA methylation (DNAm) was used to compute epigenetic age acceleration by four epigenetic clocks as a measure of biological aging. Path modelling was used to study whether the association between sex and biological aging is mediated through lifestyle-related factors, i.e. education, body mass index, smoking, alcohol use, and physical activity.
Results
In comparison to women, men were biologically older and, in general, they had unhealthier life habits. The effect of sex on biological aging was partly mediated by body mass index and, in older twins, by smoking. Sex was directly associated with biological aging and the association was stronger in older twins.
Conclusions
Previously reported sex differences in lifespan are also evident in biological aging. Declining smoking prevalence among men is a plausible explanation for the narrowing of the difference in life expectancy between the sexes. Data generated by the epigenetic clocks may help in estimating the effects of lifestyle and environmental factors on aging and in predicting aging in future generations. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Oxford University Press (OUP) | |
dc.relation.ispartofseries | Journals of Gerontology Series A : Biological Sciences and Medical Sciences | |
dc.rights | CC BY 4.0 | |
dc.subject.other | DNA methylation | |
dc.subject.other | sex gap | |
dc.subject.other | lifestyle | |
dc.subject.other | lifespan | |
dc.subject.other | biological age | |
dc.title | Do Epigenetic Clocks Provide Explanations for Sex Differences in Life Span? : A Cross-Sectional Twin Study | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202208254362 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Psykologian laitos | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.laitos | Department of Psychology | en |
dc.contributor.oppiaine | Psykologia | fi |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Psychology | en |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 1898-1906 | |
dc.relation.issn | 1079-5006 | |
dc.relation.numberinseries | 9 | |
dc.relation.volume | 77 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America | |
dc.rights.accesslevel | openAccess | fi |
dc.relation.grantnumber | 202100426 | |
dc.subject.yso | sukupuolierot | |
dc.subject.yso | elinikä | |
dc.subject.yso | DNA-metylaatio | |
dc.subject.yso | ikääntyminen | |
dc.subject.yso | epigenetiikka | |
dc.subject.yso | elintavat | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5290 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p1227 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p38350 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5056 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p24631 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5530 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1093/gerona/glab337 | |
dc.relation.funder | Juho Vainio Foundation | en |
dc.relation.funder | Juho Vainion Säätiö | fi |
jyx.fundingprogram | Foundation | en |
jyx.fundingprogram | Säätiö | fi |
jyx.fundinginformation | This work was supported by the Academy of Finland (213506, 265240, 263278, 312073 to JK, and
297908 to MO), EC FP5 GenomEUtwin (JK), National Institutes of Health/National Heart, Lung, and
Blood Institute (grant HL104125), EC MC ITN Project EPITRAIN (JK and MO), the University of
Helsinki Research Funds (MO), Sigrid Juselius Foundation (JK and MO), Yrjö Jahnsson Foundation
(6868), and Juho Vainio Foundation (ES) | |
dc.type.okm | A1 | |