Näytä suppeat kuvailutiedot

dc.contributor.authorDouzi, Wafa
dc.contributor.authorBon, Delphine
dc.contributor.authorSuikkanen, Sara
dc.contributor.authorSoukkio, Paula
dc.contributor.authorBoildieu, Nadège
dc.contributor.authorNenonen, Arja
dc.contributor.authorHupli, Markku
dc.contributor.authorKukkonen-Harjula, Katriina
dc.contributor.authorDugué, Benoit
dc.date.accessioned2022-08-22T09:53:02Z
dc.date.available2022-08-22T09:53:02Z
dc.date.issued2022
dc.identifier.citationDouzi, W., Bon, D., Suikkanen, S., Soukkio, P., Boildieu, N., Nenonen, A., Hupli, M., Kukkonen-Harjula, K., & Dugué, B. (2022). 1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling : A Preliminary Investigation. <i>Metabolites</i>, <i>12</i>(8), Article 744. <a href="https://doi.org/10.3390/metabo12080744" target="_blank">https://doi.org/10.3390/metabo12080744</a>
dc.identifier.otherCONVID_151753082
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/82753
dc.description.abstractIn these times of precision and personalized medicine, profiling patients to identify their needs is crucial to providing the best and most cost-effective treatment. In this study, we used urine metabolomics to explore the characterization of older adults with hip fractures and to explore the forecasting of patient outcomes. Overnight urine specimens were collected from 33 patients (mean age 80 ± 8 years) after hip fracture surgery during their stay at a rehabilitation hospital. The specimens were analyzed with 1H NMR spectroscopy. We performed a metabolomics study regarding assessments of frailty status, Functional Independence Measure (FIM), and Short Physical Performance Battery (SPPB). The main metabolic variations concerned 10 identified metabolites: paracetamol derivatives (4 peaks: 2.15 ppm; 2.16 ppm; 7.13 ppm and 7.15 ppm); hippuric acid; acetate; acetone; dimethylamine; glycine; alanine; lactate; valine; TMAO. At baseline, the urinary levels of these metabolites were significantly higher (i) in frail compared with non-frail patients, (ii) in persons with poorer FIM scores, and (iii) in persons with poorer compared SPPB scores. Our findings suggested that patients with increased levels of urine metabolites associated with metabolic, inflammatory, and renal disorders presented clear signs of frailty, impaired functional independence, and poor physical performance. Metabolomics could be a valuable tool to further characterize older adults, especially after major medical events.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofseriesMetabolites
dc.rightsCC BY 4.0
dc.subject.otherhip fracture
dc.subject.otherfrailty
dc.subject.otherfunctioning
dc.subject.othermetabolomics
dc.subject.othernuclear magnetic resonance spectroscopy
dc.title1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling : A Preliminary Investigation
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202208224291
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineFysioterapiafi
dc.contributor.oppiainePhysiotherapyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2218-1989
dc.relation.numberinseries8
dc.relation.volume12
dc.type.versionpublishedVersion
dc.rights.copyright© 2022 by the authors. Licensee MDPI, Basel, Switzerland
dc.rights.accesslevelopenAccessfi
dc.subject.ysoikääntyneet
dc.subject.ysoleikkaushoito
dc.subject.ysolonkka
dc.subject.ysosuorituskyky
dc.subject.ysovirtsa
dc.subject.ysomurtumat
dc.subject.ysoaineenvaihduntatuotteet
dc.subject.ysoFIM-toimintakykymittari
dc.subject.ysofyysinen toimintakyky
dc.subject.ysoNMR-spektroskopia
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p2433
jyx.subject.urihttp://www.yso.fi/onto/yso/p842
jyx.subject.urihttp://www.yso.fi/onto/yso/p7232
jyx.subject.urihttp://www.yso.fi/onto/yso/p14041
jyx.subject.urihttp://www.yso.fi/onto/yso/p15222
jyx.subject.urihttp://www.yso.fi/onto/yso/p13977
jyx.subject.urihttp://www.yso.fi/onto/yso/p24583
jyx.subject.urihttp://www.yso.fi/onto/yso/p11546
jyx.subject.urihttp://www.yso.fi/onto/yso/p27172
jyx.subject.urihttp://www.yso.fi/onto/yso/p26254
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/metabo12080744
jyx.fundinginformationThe authors acknowledge South Karelia Social and Health Care District (Eksote), Finland (grant number 1236/00.01.05.01/2013); The Social Insurance Institution of Finland (Kela) (grant numbers 94/331/2013 and 17/26/2019), the State Research Funding for Academic Health Research (Ministry of Social Affairs and Health, through Helsinki University Hospital (HUS)), Finland (grant numbers HUS 2016 (no grant number assigned), HUS/2931/2017, HUS/2571/2017, HUS/2631/2019, 864/2020), the “Institut National de la Santé et de la Recherche Médicale” (INSERM), the European Union (ERDF) and “Région Nouvelle Aquitaine” for financial supports.
dc.type.okmA1


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