1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling : A Preliminary Investigation
Douzi, W., Bon, D., Suikkanen, S., Soukkio, P., Boildieu, N., Nenonen, A., Hupli, M., Kukkonen-Harjula, K., & Dugué, B. (2022). 1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling : A Preliminary Investigation. Metabolites, 12(8), Article 744. https://doi.org/10.3390/metabo12080744
Julkaistu sarjassa
MetabolitesTekijät
Päivämäärä
2022Tekijänoikeudet
© 2022 by the authors. Licensee MDPI, Basel, Switzerland
In these times of precision and personalized medicine, profiling patients to identify their needs is crucial to providing the best and most cost-effective treatment. In this study, we used urine metabolomics to explore the characterization of older adults with hip fractures and to explore the forecasting of patient outcomes. Overnight urine specimens were collected from 33 patients (mean age 80 ± 8 years) after hip fracture surgery during their stay at a rehabilitation hospital. The specimens were analyzed with 1H NMR spectroscopy. We performed a metabolomics study regarding assessments of frailty status, Functional Independence Measure (FIM), and Short Physical Performance Battery (SPPB). The main metabolic variations concerned 10 identified metabolites: paracetamol derivatives (4 peaks: 2.15 ppm; 2.16 ppm; 7.13 ppm and 7.15 ppm); hippuric acid; acetate; acetone; dimethylamine; glycine; alanine; lactate; valine; TMAO. At baseline, the urinary levels of these metabolites were significantly higher (i) in frail compared with non-frail patients, (ii) in persons with poorer FIM scores, and (iii) in persons with poorer compared SPPB scores. Our findings suggested that patients with increased levels of urine metabolites associated with metabolic, inflammatory, and renal disorders presented clear signs of frailty, impaired functional independence, and poor physical performance. Metabolomics could be a valuable tool to further characterize older adults, especially after major medical events.
...
Julkaisija
MDPI AGISSN Hae Julkaisufoorumista
2218-1989Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/151753082
Metadata
Näytä kaikki kuvailutiedotKokoelmat
- Liikuntatieteiden tiedekunta [2895]
Lisätietoja rahoituksesta
The authors acknowledge South Karelia Social and Health Care District (Eksote), Finland (grant number 1236/00.01.05.01/2013); The Social Insurance Institution of Finland (Kela) (grant numbers 94/331/2013 and 17/26/2019), the State Research Funding for Academic Health Research (Ministry of Social Affairs and Health, through Helsinki University Hospital (HUS)), Finland (grant numbers HUS 2016 (no grant number assigned), HUS/2931/2017, HUS/2571/2017, HUS/2631/2019, 864/2020), the “Institut National de la Santé et de la Recherche Médicale” (INSERM), the European Union (ERDF) and “Région Nouvelle Aquitaine” for financial supports. ...Lisenssi
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
Effects of 12-month home-based physiotherapy on duration of living at home and functional capacity among older persons with signs of frailty or with a recent hip fracture : protocol of a randomized controlled trial (HIPFRA study)
Soukkio, Paula; Suikkanen, Sara; Kääriä, Sanna; Kautiainen, Hannu; Sipilä, Sarianna; Kukkonen-Harjula, Katriina; Hupli, Markku (BioMed Central Ltd, 2018)Background: Health concerns, such as frailty and osteoporotic fractures decrease functional capacity and increase use of health and social care services in the aging population. The ability to continue living at home is ... -
Physical function and lean body mass as predictors of bone loss after hip fracture : a prospective follow-up study
Suominen, Tuuli H.; Edgren, Johanna; Salpakoski, Anu; Kallinen, Mauri; Cervinka, Tomas; Rantalainen, Timo; Törmäkangas, Timo; Heinonen, Ari; Sipilä, Sarianna (BioMed Central, 2020)Background Predictors of bone deterioration after hip fracture have not been well characterized. The aim of this study was to examine the associations of physical function and lean body mass (LBM) with loss of bone density ... -
Chiral self-sorting behaviour of [2.2]paracyclophane-based bis(pyridine) ligands
Anhäuser, J.; Puttreddy, Rakesh; Lorenz, Y.; Schneider, A.; Engeser, M.; Rissanen, Kari; Lützen, A. (Royal Society of Chemistry, 2019)Two constitutionally isomeric chiral bis(pyridine) ligands based on planar chiral 4,15-difunctionalized [2.2]paracyclophanes were synthesized, the respective enantiomers were separated via HPLC on a chiral stationary phase, ... -
Effects of a 12-month home-based exercise program on functioning after hip fracture : Secondary analyses of an RCT
Soukkio, Paula K.; Suikkanen, Sara A.; Kukkonen‐Harjula, Katriina T.; Kautiainen, Hannu; Hupli, Markku T.; Aartolahti, Eeva M.; Kääriä, Sanna M.; Pitkälä, Kaisu H.; Sipilä, Sarianna (Wiley-Blackwell, 2022)Background Long-term functional limitations are common after hip fractures. Exercise may alleviate these negative consequences but there is no consensus on an optimal training program. The objective was to study the effects ... -
Effects of home-based physical exercise on days at home, healthcare utilization and functional independence among patients with hip fractures : a randomized controlled trial
Soukkio, Paula K.; Suikkanen, Sara A.; Aartolahti, Eeva M.; Kautiainen, Hannu; Kääriä, Sanna M.; Hupli, Markku T.; Pitkälä, Kaisu H.; Sipilä, Sarianna; Kukkonen-Harjula, Katriina T. (Elsevier, 2021)Objective To evaluate the effects of a physical exercise program on days lived at home, the use and costs of healthcare and social services mortality and functional independence among patients with hip fractures. Des ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.