Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms : Findings from Helsinki birth cohort study

Abstract
Background Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms. Methods From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive symptoms according to the Beck Depression Inventory (BDI) and Mental Health Inventory-5. Each participant had their AGE level measured non-invasively with skin autofluorescence (SAF). Statistical analyses looked at relationships between types of depressive symptoms and AGE levels by sex. Results Of women, 27% scored ≥10 on the BDI and 18% of men, respectively. Men had higher crude AGE levels (mean [standard deviation], arbitrary units) (2.49 [0.51]) compared to women (2.33 [0.46]) (p < 0.001). The highest crude AGE levels were found in those with melancholic depressive symptoms (2.61 [0.57]), followed by those with non-melancholic depressive symptoms (2.45 [0.45]) and those with no depressive symptoms (2.38 [0.49]) (p = 0.013). These findings remained significant in the fully adjusted model. Conclusions The current study shows an association between depressive symptoms and higher AGE levels. The association is likely part of a multi-factorial effect, and hence no directionality, causality, or effect can be inferred solely based on the results of this study.
Main Authors
Format
Articles Research article
Published
2021
Series
Subjects
Publication in research information system
Publisher
Elsevier
The permanent address of the publication
https://urn.fi/URN:NBN:fi:jyu-202105062646Käytä tätä linkitykseen.
Review status
Peer reviewed
ISSN
0022-3999
DOI
https://doi.org/10.1016/j.jpsychores.2021.110488
Language
English
Published in
Journal of Psychosomatic Research
Citation
  • Eriksson, M. D., Eriksson, J. G., Kautiainen, H., Salonen, M. K., Mikkola, T. M., Kajantie, E., Wasenius, N., von Bonsdorff, M., & Laine, M. K. (2021). Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms : Findings from Helsinki birth cohort study. Journal of Psychosomatic Research, 145, Article 110488. https://doi.org/10.1016/j.jpsychores.2021.110488
License
CC BY 4.0Open Access
Additional information about funding
The HBCS has been supported by grants from Finska Läkaresällskapet, the Finnish Special Governmental Subsidy for Health Sciences, Academy of Finland (126775, 127437, 129255, 129306, 129907, 130326, 134791, 209072, 210595, 213225, 263924, 275074 and 315690), Samfundet Folkhälsan, Liv och Hälsa, EU FP7 [Developmental Origins of Healthy Aging (DORIAN)] project number 278603, and EU H2020-PHC-2014-DynaHealth grant 633595 and EU Horizon 2020 Award 733206 LIFECYCLE (all for the Helsinki Birth Cohort Study), European Commission, Horizon2020 award 733280 RECAP), Foundation for Cardiovascular Research, Foundation for Diabetes Research, Foundation for Pediatric Research, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation.
Copyright© 2021 The Author(s). Published by Elsevier Inc.

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