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dc.contributor.authorPesonen, Heidi
dc.contributor.authorLaakkonen, Eija K.
dc.contributor.authorHautasaari, Pekka
dc.contributor.authorAukee, Pauliina
dc.contributor.authorKovanen, Vuokko
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorFinni, Taija
dc.contributor.authorTarkka, Ina M.
dc.date.accessioned2021-04-07T12:26:31Z
dc.date.available2021-04-07T12:26:31Z
dc.date.issued2021
dc.identifier.citationPesonen, H., Laakkonen, E. K., Hautasaari, P., Aukee, P., Kovanen, V., Sipilä, S., Finni, T., & Tarkka, I. M. (2021). Perimenopausal women show modulation of excitatory and inhibitory neuromuscular mechanisms. <i>BMC Womens Health</i>, <i>21</i>. https://doi.org/10.1186/s12905-021-01275-8
dc.identifier.otherCONVID_66311688
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/74985
dc.description.abstractBackground Menopausal transition exposes women to an early decline in muscle force and motor function. Changes in muscle quality and function, especially in lower limbs, are crucial, as they expose individuals to increased risk of falls. To elucidate some of the related neuromuscular mechanisms, we investigated cortical inhibition and peripheral muscle twitch force potentiation in women during the early and late stages of perimenopause. Methods Participants were 63 women aged 48–55 years categorized as early (EP, n = 25) or late (LP, n = 38) perimenopausal according to serum follicle-stimulating hormone (FSH) levels and menstrual diaries. EP women had an irregular menstrual cycle and FSH < 25 IU/L, while LP women had an irregular cycle and > 25 IU/L. We examined motor evoked potential (MEP) and silent period (SP) elicited by transcranial magnetic stimulation (TMS), in the tibialis anterior muscle at 20%, 40%, and 60% of maximal voluntary contraction (MVC) levels, and twitch force potentiation in plantar flexors. Results EP group showed a longer SP duration in 40% MVC condition and larger motor evoked potential amplitude in 20% MVC condition compared to the LP group. No group difference was detected in twitch force potentiation; however, it correlated negatively with FSH levels. Other factors, such as age, height, body mass index, or physical activity did not explain group differences. Conclusions Our preliminary results indicate subtle modulation in both TMS-induced inhibitory and excitatory mechanisms and twitch force potentiation in women already in the late perimenopausal stage. This suggests that the reduction of estrogens may have an accelerating role in the aging process of neuromuscular control.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.relation.ispartofseriesBMC Womens Health
dc.rightsCC BY 4.0
dc.subject.othermenopause
dc.subject.otherfollicle-stimulating hormone
dc.subject.othermotor cortex
dc.subject.otherTMS silent period
dc.subject.othertwitch force potentiation
dc.titlePerimenopausal women show modulation of excitatory and inhibitory neuromuscular mechanisms
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202104072301
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn1472-6874
dc.relation.volume21
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 the Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber275323
dc.relation.grantnumber309504
dc.subject.ysovaihdevuodet
dc.subject.ysofollikkelia stimuloiva hormoni
dc.subject.ysoikääntyminen
dc.subject.ysolihasvoima
dc.subject.ysohermo-lihastoiminta
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p17397
jyx.subject.urihttp://www.yso.fi/onto/yso/p38790
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p23362
jyx.subject.urihttp://www.yso.fi/onto/yso/p25107
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1186/s12905-021-01275-8
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundinginformationThis study received funding from Academy of Finland (No. 275323, Vuokko Kovanen & no. 309504, Eija K. Laakkonen) and Juho Vainion säätiö (2016-2018, Eija K. Laakkonen).


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