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dc.contributor.authorGorina-Careta, Natàlia
dc.contributor.authorKurkela, Jari L.O.
dc.contributor.authorHämäläinen, Jarmo
dc.contributor.authorAstikainen, Piia
dc.contributor.authorEscera, Carles
dc.date.accessioned2021-02-22T09:40:33Z
dc.date.available2021-02-22T09:40:33Z
dc.date.issued2021
dc.identifier.citationGorina-Careta, N., Kurkela, J. L., Hämäläinen, J., Astikainen, P., & Escera, C. (2021). Neural generators of the frequency-following response elicited to stimuli of low and high frequency : a magnetoencephalographic (MEG) study. <i>NeuroImage</i>, <i>231</i>, Article 117866. <a href="https://doi.org/10.1016/j.neuroimage.2021.117866" target="_blank">https://doi.org/10.1016/j.neuroimage.2021.117866</a>
dc.identifier.otherCONVID_51516765
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/74329
dc.description.abstractThe frequency-following response (FFR) to periodic complex sounds has gained recent interest in auditory cognitive neuroscience as it captures with great fidelity the tracking accuracy of the periodic sound features in the ascending auditory system. Seminal studies suggested the FFR as a correlate of subcortical sound encoding, yet recent studies aiming to locate its sources challenged this assumption, demonstrating that FFR receives some contribution from the auditory cortex. Based on frequency-specific phase-locking capabilities along the auditory hierarchy, we hypothesized that FFRs to higher frequencies would receive less cortical contribution than those to lower frequencies, hence supporting a major subcortical involvement for these high frequency sounds. Here, we used a magnetoencephalographic (MEG) approach to trace the neural sources of the FFR elicited in healthy adults (N=19) to low (89 Hz) and high (333 Hz) frequency sounds. FFRs elicited to the high and low frequency sounds were clearly observable on MEG and comparable to those obtained in simultaneous electroencephalographic recordings. Distributed source modeling analyses revealed midbrain, thalamic, and cortical contributions to FFR, arranged in frequency-specific configurations. Our results showed that the main contribution to the high-frequency sound FFR originated in the inferior colliculus and the medial geniculate body of the thalamus, with no significant cortical contribution. In contrast, the low-frequency sound FFR had a major contribution located in the auditory cortices, and also received contributions originating in the midbrain and thalamic structures. These findings support the multiple generator hypothesis of the FFR and are relevant for our understanding of the neural encoding of sounds along the auditory hierarchy, suggesting a hierarchical organization of periodicity encoding.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesNeuroImage
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherfrequency following responses
dc.subject.othermagnetoencephalography
dc.subject.otherneural sources
dc.subject.otherauditory plasticity
dc.subject.otherspeech sound encoding
dc.subject.otherfundamental frequency
dc.titleNeural generators of the frequency-following response elicited to stimuli of low and high frequency : a magnetoencephalographic (MEG) study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202102221723
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1053-8119
dc.relation.volume231
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysohavaintopsykologia
dc.subject.ysoMEG
dc.subject.ysokognitiivinen neurotiede
dc.subject.ysoärsykkeet
dc.subject.ysotaajuus
dc.subject.ysokuulo
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p4033
jyx.subject.urihttp://www.yso.fi/onto/yso/p3329
jyx.subject.urihttp://www.yso.fi/onto/yso/p23133
jyx.subject.urihttp://www.yso.fi/onto/yso/p2943
jyx.subject.urihttp://www.yso.fi/onto/yso/p704
jyx.subject.urihttp://www.yso.fi/onto/yso/p1937
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.neuroimage.2021.117866
jyx.fundinginformationThis work was supported by the PSI2015-63664-P project (MINECO/FEDER) and the ICREA Academia Distinguished Professorship awarded to Carles Escera, by the María de Maeztu Unit of Excellence (Institute of Neurosciences, University of Barcelona) MDM-2017-0729, Ministry of Science, Innovation and Universities, and the Academy of Finland (project number 273134 for P.A.).
dc.type.okmA1


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