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dc.contributor.authorHaoran, Dou
dc.contributor.authorYi, Lei
dc.contributor.authorXiaojun, Cheng
dc.contributor.authorJinxia, Wang
dc.contributor.authorLeppänen, Paavo H.T.
dc.date.accessioned2020-06-10T08:00:50Z
dc.date.available2020-06-10T08:00:50Z
dc.date.issued2020
dc.identifier.citationHaoran, D., Yi, L., Xiaojun, C., Jinxia, W., & Leppänen, P. H. (2020). Social exclusion influences conditioned fear acquisition and generalization : a mediating effect from the medial prefrontal cortex. <i>NeuroImage</i>, <i>218</i>, Article 116735. <a href="https://doi.org/10.1016/j.neuroimage.2020.116735" target="_blank">https://doi.org/10.1016/j.neuroimage.2020.116735</a>
dc.identifier.otherCONVID_35194921
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/69832
dc.description.abstractFear acquisition and generalization play key roles in promoting the survival of mammals and contribute to anxiety disorders. While previous research has provided much evidence for the repercussions of social exclusion on mental health, how social exclusion affects fear acquisition and generalization has received scant attention. In our study, participants were divided into two groups according to two Cyberball paradigm conditions (exclusion/inclusion). Both groups underwent a Pavlovian conditioning paradigm, functional near-infrared spectroscopy (fNIRS), and skin conductance response (SCR) assessments. We aimed to determine the effects of social exclusion on fear acquisition and generalization and whether modulation of the medial prefrontal cortex (mPFC) mediates this relationship. Our results showed that socially excluded participants featured significantly higher and lower shock risk scores to safety stimuli (conditioned stimulus, CS-) and threatening stimuli (CS+), respectively, than did socially included subjects during fear acquisition. The exclusion group had increased skin conductance responses (SCRs) to CS and exhibited heightened shock risk and increased SCRs to generalized stimuli compared with the inclusion group. The fNIRS results demonstrated that the CS + evoked larger oxy-Hb changes in the mPFC in the inclusion group than in the exclusion group during fear acquisition. Furthermore, the oxy-Hb of left mPFC of CS + mediated the effect on the association between social exclusion and perceived risk of CS+ in the fear acquisition. Our results indicate that social exclusion impairs fear acquisition and generalization via the mediation of the mPFC and that social exclusion increases susceptibility to anxiety disorders through bias processing of fear discrimination in fear acquisition and generalization. By studying the role of social relationship in fear acquisition and generalization, our research provides new insights into the pathological mechanisms of anxiety disorder.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesNeuroImage
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherfear acquisition
dc.subject.otherfear generalization
dc.subject.othersocial exclusion
dc.subject.othermPFC
dc.subject.otherfNIRS
dc.subject.otherSCR
dc.titleSocial exclusion influences conditioned fear acquisition and generalization : a mediating effect from the medial prefrontal cortex
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202006104074
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn1053-8119
dc.relation.volume218
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 Published by Elsevier Inc.
dc.rights.accesslevelopenAccessfi
dc.subject.ysopelko
dc.subject.ysosyrjäytyminen
dc.subject.ysoaivokuori
dc.subject.ysoaivotutkimus
dc.subject.ysoehdollistuminen
dc.subject.ysoahdistuneisuushäiriöt
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p10848
jyx.subject.urihttp://www.yso.fi/onto/yso/p8917
jyx.subject.urihttp://www.yso.fi/onto/yso/p7039
jyx.subject.urihttp://www.yso.fi/onto/yso/p23705
jyx.subject.urihttp://www.yso.fi/onto/yso/p2942
jyx.subject.urihttp://www.yso.fi/onto/yso/p21091
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.neuroimage.2020.116735
jyx.fundinginformationThis research was supported by the National Natural Science Foundation of China (NSFC31571153, NSFC31871130, NSFC31671150); the (Key) Project of DEGP (2015KCXTD009); Guangdong Key Project in "Development of new tools for diagnosis and treatment of Autism " (2018B030335001); Shenzhen Peacock Plan (KQTD2015033016104926); Major Program of Guangdong, China (2016KZDXM009); JCYJ20150729104249783; the Foundation for Distinguished Young Talents in Higher Education of Guangdong (2017KQNCX172); the Natural Science Foundation of SZU (2018053); Shenzhen-Hong Kong Brain Science Innovation Institute Project (2019SHIBS0003).


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