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dc.contributor.authorKunutsor, Setor K.
dc.contributor.authorMäkikallio, Timo H.
dc.contributor.authorSeidu, Samuel
dc.contributor.authorde Araújo, Claudio Gil Soares
dc.contributor.authorDey, Richard S.
dc.contributor.authorBlom, Ashley W.
dc.contributor.authorLaukkanen, Jari A.
dc.date.accessioned2020-05-29T10:46:38Z
dc.date.available2020-05-29T10:46:38Z
dc.date.issued2020
dc.identifier.citationKunutsor, S. K., Mäkikallio, T. H., Seidu, S., de Araújo, C. G. S., Dey, R. S., Blom, A. W., & Laukkanen, J. A. (2020). Physical activity and risk of venous thromboembolism : systematic review and meta-analysis of prospective cohort studies. <i>European Journal of Epidemiology</i>, <i>35</i>(5), 431-442. <a href="https://doi.org/10.1007/s10654-019-00579-2" target="_blank">https://doi.org/10.1007/s10654-019-00579-2</a>
dc.identifier.otherCONVID_33549787
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/69328
dc.description.abstractThe inverse association between physical activity and arterial thrombotic disease is well established. Evidence on the association between physical activity and venous thromboembolism (VTE) is divergent. We conducted a systematic review and meta-analysis of published observational prospective cohort studies evaluating the associations of physical activity with VTE risk. MEDLINE, Embase, Web of Science, and manual search of relevant bibliographies were systematically searched until 26 February 2019. Extracted relative risks (RRs) with 95% confidence intervals (CIs) for the maximum versus minimal amount of physical activity groups were pooled using random effects meta-analysis. Twelve articles based on 14 unique prospective cohort studies comprising of 1,286,295 participants and 23,753 VTE events were eligible. The pooled fully-adjusted RR (95% CI) of VTE comparing the most physically active versus the least physically active groups was 0.87 (0.79–0.95). In pooled analysis of 10 studies (288,043 participants and 7069 VTE events) that reported risk estimates not adjusted for body mass index (BMI), the RR (95% CI) of VTE was 0.81 (0.70–0.93). The associations did not vary by geographical location, age, sex, BMI, and methodological quality of studies. There was no evidence of publication bias among contributing studies. Pooled observational prospective cohort studies support an association between regular physical activity and low incidence of VTE. The relationship does not appear to be mediated or confounded by BMI.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesEuropean Journal of Epidemiology
dc.rightsCC BY 4.0
dc.subject.otherphysical activity
dc.subject.othervenous thromboembolism
dc.subject.othercohort study
dc.subject.otherrisk factor
dc.subject.othersystematic review
dc.subject.othermeta-analysis
dc.titlePhysical activity and risk of venous thromboembolism : systematic review and meta-analysis of prospective cohort studies
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202005293584
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange431-442
dc.relation.issn0393-2990
dc.relation.numberinseries5
dc.relation.volume35
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysokohorttitutkimus
dc.subject.ysometa-analyysi
dc.subject.ysosydän- ja verisuonitaudit
dc.subject.ysoriskitekijät
dc.subject.ysotromboosi
dc.subject.ysoliikunta
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p25606
jyx.subject.urihttp://www.yso.fi/onto/yso/p27697
jyx.subject.urihttp://www.yso.fi/onto/yso/p9886
jyx.subject.urihttp://www.yso.fi/onto/yso/p13277
jyx.subject.urihttp://www.yso.fi/onto/yso/p1659
jyx.subject.urihttp://www.yso.fi/onto/yso/p916
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s10654-019-00579-2
jyx.fundinginformationThis study was supported by the NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol (BRC-1215-20011). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. THM and SKK acknowledge support from the Division of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu, Finland via the Finnish Governmental Research Funding (VTR). SS acknowledges support from the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care – East Midlands (NIHR CLAHRC – EM), the Leicester Clinical Trials Unit and the NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University and the University of Leicester.


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