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dc.contributor.authorKortteenniemi, Aaron M.
dc.contributor.authorOrtega-Alonso, Alfredo
dc.contributor.authorJavadi, Amir-Homayoun
dc.contributor.authorTolmunen, Tommi
dc.contributor.authorAli-Sisto, Toni
dc.contributor.authorKotilainen, Tuukka
dc.contributor.authorWikgren, Jan
dc.contributor.authorKarhunen, Leila
dc.contributor.authorVelagapudi, Vidya
dc.contributor.authorLehto, Soili M.
dc.date.accessioned2020-05-07T11:56:42Z
dc.date.available2020-05-07T11:56:42Z
dc.date.issued2020
dc.identifier.citationKortteenniemi, A. M., Ortega-Alonso, A., Javadi, A.-H., Tolmunen, T., Ali-Sisto, T., Kotilainen, T., Wikgren, J., Karhunen, L., Velagapudi, V., & Lehto, S. M. (2020). Anodal tDCS over the left prefrontal cortex does not cause clinically significant changes in circulating metabolites. <i>Frontiers in Psychiatry</i>, <i>11</i>, Article 403. <a href="https://doi.org/10.3389/fpsyt.2020.00403" target="_blank">https://doi.org/10.3389/fpsyt.2020.00403</a>
dc.identifier.otherCONVID_35357474
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/68892
dc.description.abstractBackground: Transcranial direct current stimulation (tDCS), a putative treatment for depression, has been proposed to affect peripheral metabolism. Metabolic products from brain tissue may also cross the blood-brain-barrier, reflecting the conditions in the brain. However, there are no previous data regarding the effect of tDCS on circulating metabolites. Objective: To determine if 5 daily sessions of tDCS modulate peripheral metabolites in healthy adult men. Methods: This double-blind, randomized controlled trial involved 79 healthy males (aged 20–40 years) divided into two groups, one receiving tDCS (2 mA), the other being sham stimulated. The anode was placed over the left dorsolateral prefrontal cortex, and the cathode over the corresponding contralateral area. Venous blood samples were obtained before and after the first stimulation session, and after the fifth stimulation session. Serum levels of 102 metabolites were determined by mass spectrometry. The results were analysed with generalised estimating equations corrected for family-wise error rate. In addition, we performed power calculations estimating sample sizes necessary for future research. Results: TDCS-related variation in serum metabolite levels was extremely small and statistically non-significant. Power calculations indicated that for the observed variation to be deemed significant, samples sizes of up to 11000 subjects per group would be required, depending on the metabolite of interest. Conclusion: Our study found that 5 sessions of tDCS induced no major effects on peripheral metabolites among healthy men. These observations support the view of tDCS is a safe treatment, and do not support the previously suggested modulatory impact on peripheral metabolic processes.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofseriesFrontiers in Psychiatry
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fpsyt.2020.00403
dc.rightsCC BY 4.0
dc.titleAnodal tDCS over the left prefrontal cortex does not cause clinically significant changes in circulating metabolites
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202005073102
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn1664-0640
dc.relation.volume11
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 Kortteenniemi, Ortega-Alonso, Javadi, Tolmunen, Ali-Sisto, Kotilainen, Wikgren, Karhunen, Velagapudi and Lehto.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoaivot
dc.subject.ysoaivotutkimus
dc.subject.ysomasennus
dc.subject.ysoneurotieteet
dc.subject.ysoaineenvaihdunta
dc.subject.ysoaineenvaihduntatuotteet
dc.subject.ysoaivokuori
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p7040
jyx.subject.urihttp://www.yso.fi/onto/yso/p23705
jyx.subject.urihttp://www.yso.fi/onto/yso/p7995
jyx.subject.urihttp://www.yso.fi/onto/yso/p18502
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
jyx.subject.urihttp://www.yso.fi/onto/yso/p24583
jyx.subject.urihttp://www.yso.fi/onto/yso/p7039
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fpsyt.2020.00403
jyx.fundinginformationThis study was supported by the Signe and Ane Gyllenberg Foundation, the Finnish Medical Foundation, and VTR research funding. SL was supported by a grant from the Finnish Medical Foundation. AK was supported by Emil Aaltonen Foundation, Finnish Medical Foundation and Jalmari and Rauha Ahonen Foundation. None of the funding sources had any involvement in the study design or execution.


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