1,2,6-Thiadiazine 1-Oxides : Unsaturated Three-Dimensional S,N-Heterocycles from Sulfonimidamides
Schöbel, J.-H., Passia, M. T., Wolter, N. A., Puttreddy, R., Rissanen, K., & Bolm, C. (2020). 1,2,6-Thiadiazine 1-Oxides : Unsaturated Three-Dimensional S,N-Heterocycles from Sulfonimidamides. Organic Letters, 12(7), 2702-2706. https://doi.org/10.1021/acs.orglett.0c00666
Published in
Organic LettersDate
2020Copyright
© 2020 American Chemical Society
Unprecedented three-dimensional 1,2,6-thiadiazine 1-oxides have been prepared by an aza-Michael-addition/cyclization/condensation reaction sequence starting from sulfonimidamides and propargyl ketones. The products have been further functionalized by standard cross-coupling reactions, selective bromination of the heterocyclic ring, and conversion into a β-hydroxy substituted derivative. A representative product was characterized by single-crystal X-ray structure analysis.
Publisher
American Chemical SocietyISSN Search the Publication Forum
1523-7060Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/34973279
Metadata
Show full item recordCollections
Related funder(s)
Research Council of FinlandFunding program(s)
Postdoctoral Researcher, AoFAdditional information about funding
We thank the Alexander von Humboldt Foundation for support of K.R. (AvH research award), and we gratefully acknowledge Marcus Frings (RWTH Aachen University) for measuring the HPLC data. Further thanks go to Daniela Lutsch (RWTH Aachen University) for supporting practical experiments. Financial support from the Academy of Finland (RP Grant No. 298817) is also gratefully acknowledged.License
Except where otherwise noted, this item's license is described as In Copyright