[3+2]-Cycloadditions of N-Cyano Sulfoximines with 1,3-Dipoles
Krauskopf, F., Truong, K.-N., Rissanen, K., & Bolm, C. (2020). [3+2]-Cycloadditions of N-Cyano Sulfoximines with 1,3-Dipoles. European Journal of Organic Chemistry, 20(18), 2761-2765. https://doi.org/10.1002/ejoc.202000335
Published inEuropean Journal of Organic Chemistry
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
Involving the cyano group of N‐cyano sulfoximines in [3+2]‐cycloaddition reactions with 1,3‐dipoles provides practical routes for the construction of 5‐membered heterocycles bearing sulfoximinoyl moieties. An ytterbium‐catalyzed cycloaddition utilizing hydrazonoyl chlorides was developed, as well as a reaction involving imidoyl chlorides proceeding without the aid of a catalyst. Following these protocols, a range of sulfoximines with N‐1,2,4‐triazolyl and N‐1,2,4‐oxadiazolyl substituents was prepared.