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dc.contributor.authorSaari, Heikki
dc.contributor.authorTurunen, Tiia
dc.contributor.authorLõhmus, Andres
dc.contributor.authorTurunen, Mikko
dc.contributor.authorJalasvuori, Matti
dc.contributor.authorButcher, Sarah J.
dc.contributor.authorYlä-Herttuala, Seppo
dc.contributor.authorViitala, Tapani
dc.contributor.authorCerullo, Vincenzo
dc.contributor.authorSiljander, Pia R. M.
dc.contributor.authorYliperttula, Marjo
dc.date.accessioned2020-04-24T10:21:14Z
dc.date.available2020-04-24T10:21:14Z
dc.date.issued2020
dc.identifier.citationSaari, H., Turunen, T., Lõhmus, A., Turunen, M., Jalasvuori, M., Butcher, S. J., Ylä-Herttuala, S., Viitala, T., Cerullo, V., Siljander, P. R. M., & Yliperttula, M. (2020). Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery. <i>Journal of Extracellular Vesicles</i>, <i>9</i>(1), Article 1747206. <a href="https://doi.org/10.1080/20013078.2020.1747206" target="_blank">https://doi.org/10.1080/20013078.2020.1747206</a>
dc.identifier.otherCONVID_35257624
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/68675
dc.description.abstractExtracellular vesicles (EVs) have been showcased as auspicious candidates for delivering therapeutic cargo, including oncolytic viruses for cancer treatment. Delivery of oncolytic viruses in EVs could provide considerable advantages, hiding the viruses from the immune system and providing alternative entry pathways into cancer cells. Here we describe the formation and viral cargo of EVs secreted by cancer cells infected with an oncolytic adenovirus (IEVs, infected cell-derived EVs) as a function of time after infection. IEVs were secreted already before the lytic release of virions and their structure resembled normally secreted EVs, suggesting that they were not just apoptotic fragments of infected cells. IEVs were able to carry the viral genome and induce infection in other cancer cells. As such, the role of EVs in the life cycle of adenoviruses may be an important part of a successful infection and may also be harnessed for cancer- and gene therapy.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.ispartofseriesJournal of Extracellular Vesicles
dc.rightsCC BY-NC 4.0
dc.subject.otherextracellular vesicles
dc.subject.otheradenovirus
dc.subject.othercancer therapy
dc.subject.otherDNA delivery
dc.titleExtracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202004242888
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineBiologisten vuorovaikutusten huippututkimusyksikköfi
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineCentre of Excellence in Biological Interactions Researchen
dc.contributor.oppiaineCell and Molecular Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn2001-3078
dc.relation.numberinseries1
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 The Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber328601
dc.subject.ysoadenovirukset
dc.subject.ysosyöpähoidot
dc.subject.ysosolukalvot
dc.subject.ysoonkolyyttinen virushoito
dc.subject.ysoonkolyyttiset virukset
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p19797
jyx.subject.urihttp://www.yso.fi/onto/yso/p27422
jyx.subject.urihttp://www.yso.fi/onto/yso/p2410
jyx.subject.urihttp://www.yso.fi/onto/yso/p28561
jyx.subject.urihttp://www.yso.fi/onto/yso/p28562
dc.rights.urlhttps://creativecommons.org/licenses/by-nc/4.0/
dc.relation.doi10.1080/20013078.2020.1747206
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundinginformationThis work was supported by the Academy of Finland [287089, 292275, 268376, 314985, 328601, 315409]; Alfred Kordelinin Säätiö [160385]; Emil Aaltosen Säätiö [170223]; Suomen Kulttuurirahasto [2018].


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