Body size at birth and age‐related macular degeneration in old age
Haapanen, M. J., von Bonsdorff, M. B., Fisher, D., Jonasson, F., Eiriksdottir, G., Gudnason, V., & Cotch, M. F. (2020). Body size at birth and age‐related macular degeneration in old age. Acta Ophthalmologica, 98(5), 455-463. https://doi.org/10.1111/aos.14340
Published inActa Ophthalmologica
DisciplineGerontologia ja kansanterveysGerontologian tutkimuskeskusGerontology and Public HealthGerontology Research Center
© 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd
Purpose: To study associations between body size at birth and age-relatedmacular degeneration (AMD) in old age. Methods: The study sample consists of 1497 community-dwelling individuals(56.1% women) aged 67–89 years with birth data and retinal data collectedtwice in old age 5 years apart. Birth data (weight, length, birth order) wereextracted from original birth records. Digital retinal photographs were graded todetermine AMD status. Data on covariates were collected at the baselinephysical examination in old age. Multivariable regression analyses were used tostudy the association between birth data and AMD adjusting for knownconfounding factors, including birth year cohort effects. Results: The prevalence and 5-year incidence of any AMD were 33.1% and 17.0%,respectively.Menandwomenbornin1930–1936 were significantly leaner and slightlylonger at birth compared to those in earlier birth cohorts. There were no consistentassociations between weight, length or ponderal index (PI) at birth and AMD in oldage even when stratified by birth cohort. Age-related macular degeneration (AMD)prevalence (39.8%) and 5-year incidence (28.6%) were highest in individuals whowere in the highest quartile of PI at birth and who were obese in old age. Conclusion: Body size at birth was not consistently associated with AMD in oldage, suggesting that intrauterine growth might have little direct importance in thedevelopment of AMD in old age. It is possible that some yet unknown factorsrelated to larger size at birth and obesity in old age may explain differences in theprevalence and incidence of AMD in the ageing population. ...
PublisherWiley-Blackwell Publishing, Inc.
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Additional information about fundingThis work was supported by the National Institutes of Health (Intramural Research Program of the National Institute of Aging and the National Eye Institute, ZIAEY00401), National Institute of Health contract number N01‐AG‐1‐2100, the Icelandic Heart Association, the Icelandic Parliament, the University of Iceland Research Fund and the Helga Jonsdottir and Sigurlidi Kristjansson Research Fund.
Showing items with similar title or keywords.
Relationship between physical activity and physical performance in later life in different birth weight groups Jantunen, H.; Wasenius, N. S.; Salonen, M. K.; Perälä, M.-M.; Kautiainen, H.; Simonen, M.; Pohjolainen, P.; Kajantie, E.; von Bonsdorff, Mikaela; Eriksson, J. G. (Cambridge University Press, 2018)There is strong evidence that physical activity (PA) has an influence on physical performance in later life. Also, a small body size at birth has been associated with lower physical functioning in older age and both small ...
Haapanen, M. J.; Perälä, M. M.; Salonen, M. K.; Kajantie, E.; Simonen, M.; Pohjolainen, P.; Eriksson, J. G.; von Bonsdorff, Mikaela (Oxford University Press, 2018)Background there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life ...
Early Life Origins of All-Cause and Cause-Specific Disability Pension: Findings from the Helsinki Birth Cohort Study von Bonsdorff, Mikaela; Törmäkangas, Timo; Salonen, Minna; von Bonsdorff, Monika; Osmond, Clive; Kajantie, Eero; Eriksson, Johan G. (Public Library of Science, 2015)Background There is some evidence linking sub-optimal prenatal development to an increased risk of disability pension (DP). Our aim was to investigate whether body size at birth was associated with transitioning into ...
Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Study von Bonsdorff, Mikaela; Muller, Majon; Aspelund, Thor; Garcia, Melissa; Eiriksdottir, Gudny; Rantanen, Taina; Gunnarsdottir, Ingibjorg; Birgisdottir, Bryndis; Thorsdottir, Inga; Sigurdsson, Gunnar; Gudnason, Vilmundur; Launer, Lenore; Harris, Tamara (Springer, 2013)We studied the effect of birth size on glucose and insulin metabolism among old non-diabetic individuals. We also explored the combined effect of birth size and midlife body mass index (BMI) on type 2 diabetes in old age. ...
Birth Size and Childhood Growth as Determinants of Physical Functioning in Older Age: the Helsinki Birth Cohort Study von Bonsdorff, Mikaela; Rantanen, Taina; Sipilä, Sarianna; Salonen, Minna K.; Kajantie, Eero; Osmond, Clive; Barker, David J.P.; Eriksson, Johan G. (Oxford University Press, 2011)The study reports on the associations of infant and childhood anthropometric measurements, early growth, and the combined effect of birth weight and childhood body mass index with older age physical functioning among 1,999 ...