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dc.contributor.authorNokia, Miriam S.
dc.contributor.authorWaselius, Tomi
dc.contributor.authorSahramäki, Joonas
dc.contributor.authorPenttonen, Markku
dc.date.accessioned2020-03-30T11:27:09Z
dc.date.available2020-03-30T11:27:09Z
dc.date.issued2020
dc.identifier.citationNokia, M. S., Waselius, T., Sahramäki, J., & Penttonen, M. (2020). Most hippocampal CA1 pyramidal cells in rabbits increase firing during awake sharpwave ripples and some do so in response to external stimulation and theta. <i>Journal of Neurophysiology</i>, <i>123</i>(5), 1671-1681. <a href="https://doi.org/10.1152/jn.00056.2020" target="_blank">https://doi.org/10.1152/jn.00056.2020</a>
dc.identifier.otherCONVID_35102259
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/68372
dc.description.abstractHippocampus forms neural representations of real-life events including multimodal information of spatial and temporal context. These representations, i.e. organized sequences of neuronal firing are repeated during following rest and sleep, especially when so-called sharp-wave ripples (SPW-Rs) characterize hippocampal local-field potentials. This SPW-R –related replay is thought to underlie memory consolidation. Here, we set out to explore how hippocampal CA1 pyramidal cells respond to the conditioned stimulus during trace eyeblink conditioning and how these responses manifest during SPW-Rs in awake adult female New Zealand White rabbits. Based on reports in rodents, we expected SPW-Rs to take place in bursts, possibly according to a slow endogenous rhythm. In awake rabbits, half of all SPWRs took place in bursts, but no endogenous slow rhythm appeared. Conditioning trials suppressed SPW-Rs while increasing theta for a period of several seconds. As expected based on previous findings, only a quarter of the putative CA1 pyramidal cells increased firing in response to the conditioned stimulus. Compared to other cells, rate increasing cells were more active during spontaneous epochs of hippocampal theta while response profile during conditioning did not affect firing during SPW-Rs. Taken together, CA1 pyramidal cell firing during SPW-Rs is not limited to cells that fired during the preceding experience. Further, the importance of possible reactivations taking place during theta epochs on memory consolidation warrants further investigation.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesJournal of Neurophysiology
dc.rightsIn Copyright
dc.subject.otherpyramidisolut
dc.subject.otherhippocampus
dc.subject.othertheta
dc.subject.othersharp-wave ripple
dc.subject.otherclassical conditioning
dc.subject.otherpyramidal cell
dc.titleMost hippocampal CA1 pyramidal cells in rabbits increase firing during awake sharpwave ripples and some do so in response to external stimulation and theta
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202003302585
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1671-1681
dc.relation.issn0022-3077
dc.relation.numberinseries5
dc.relation.volume123
dc.type.versionacceptedVersion
dc.rights.copyright© 2020 Journal of Neurophysiology
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber275954
dc.relation.grantnumber286384
dc.relation.grantnumber316966
dc.subject.ysohermosolut
dc.subject.ysoehdollistuminen
dc.subject.ysohippokampus
dc.subject.ysoneurotieteet
dc.subject.ysomuisti (kognitio)
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p18309
jyx.subject.urihttp://www.yso.fi/onto/yso/p2942
jyx.subject.urihttp://www.yso.fi/onto/yso/p21117
jyx.subject.urihttp://www.yso.fi/onto/yso/p18502
jyx.subject.urihttp://www.yso.fi/onto/yso/p2607
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1152/jn.00056.2020
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationThis work was supported by the Academy of Finland (grant ns. 275954 and 286384 to MSN, 316966 to MP). The authors declare no conflict of interests.


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