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dc.contributor.authorKerkhof, HJ
dc.contributor.authorMeulenbelt, I
dc.contributor.authorAkune, T
dc.contributor.authorArden, NK
dc.contributor.authorAromaa, A
dc.contributor.authorBierma-Zeinstra, SM
dc.contributor.authorCarr, A
dc.contributor.authorCooper, C
dc.contributor.authorDai, J
dc.contributor.authorDoherty, M
dc.contributor.authorDoherty, SA
dc.contributor.authorFelson, D
dc.contributor.authorGonzalez, A
dc.contributor.authorGordon, A
dc.contributor.authorHarilainen, A
dc.contributor.authorHart, DJ
dc.contributor.authorHauksson, VB
dc.contributor.authorHeliovaara, M
dc.contributor.authorHofman, A
dc.contributor.authorIkegawa, S
dc.contributor.authorIngvarsson, T
dc.contributor.authorJiang, Q
dc.contributor.authorJonsson, H
dc.contributor.authorJonsdottir, I
dc.contributor.authorKawaguchi, H
dc.contributor.authorKloppenburg, M
dc.contributor.authorKujala, Urho
dc.contributor.authorLane, NE
dc.contributor.authorLeino-Arjas, P
dc.contributor.authorLohmander, LS
dc.contributor.authorLuyten, FP
dc.contributor.authorMalizos, KN
dc.contributor.authorNakajima, M
dc.contributor.authorNevitt, MC
dc.contributor.authorPols, HA
dc.contributor.authorRivadeneira, F
dc.contributor.authorShi, D
dc.contributor.authorSlagboom, E
dc.contributor.authorSpector, TD
dc.contributor.authorStefansson, K
dc.contributor.authorSudo, A
dc.contributor.authorTamm, A
dc.contributor.authorTamm, AE
dc.contributor.authorTsezou, A
dc.contributor.authorUchida, A
dc.contributor.authorUitterlinden, AG
dc.contributor.authorWilkinson, JM
dc.contributor.authorYoshimura, N
dc.contributor.authorValdes, AM
dc.contributor.authorvan Meurs, JB
dc.date.accessioned2019-09-23T12:29:13Z
dc.date.available2019-09-23T12:29:13Z
dc.date.issued2011
dc.identifier.citationKerkhof, H., Meulenbelt, I., Akune, T., Arden, N., Aromaa, A., Bierma-Zeinstra, S., Carr, A., Cooper, C., Dai, J., Doherty, M., Doherty, S., Felson, D., Gonzalez, A., Gordon, A., Harilainen, A., Hart, D., Hauksson, V., Heliovaara, M., Hofman, A., . . . van Meurs, J. (2011). Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. <i>Osteoarthritis and Cartilage</i>, <i>19</i>(3), 254-264. <a href="https://doi.org/10.1016/j.joca.2010.10.027" target="_blank">https://doi.org/10.1016/j.joca.2010.10.027</a>
dc.identifier.otherCONVID_20299778
dc.identifier.otherTUTKAID_45060
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65619
dc.description.abstractObjective To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence’s of ROA before and after standardization in nine cohort studies. This procedure could only be performed in cohort studies and standardization of SOA definitions was not feasible at this moment. Results In this consortium, all studies with SOA phenotypes (knee, hip and hand) used a different definition and/or assessment of OA status. For knee-, hip- and hand ROA five, four and seven different definitions were used, respectively. Different hip ROA definitions do lead to different association results. For example, we showed in the RSI that hip OA defined as “at least definite joint space narrowing (JSN) and one definite osteophyte” was not associated with gender (P = 0.22), but defined as “at least one definite osteophyte” was significantly associated with gender (P = 3 × 10−9). Therefore, a standardization process was undertaken for ROA definitions. Before standardization a wide range of ROA prevalence’s was observed in the nine cohorts studied. After standardization the range in prevalence of knee- and hip ROA was small. Conclusion Phenotype definitions influence the prevalence of OA and association with clinical variables. ROA phenotypes within the TREAT-OA consortium were standardized to reduce heterogeneity and improve power in future genetics studies.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesOsteoarthritis and Cartilage
dc.rightsCC BY-NC-ND 4.0
dc.subject.othergenetiikka
dc.subject.otherdiagnostiset kriteerit
dc.subject.otherosteoarthritis
dc.subject.otherdiagnostic criteria
dc.titleRecommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909114116
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-09-11T12:15:33Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange254-264
dc.relation.issn1063-4584
dc.relation.numberinseries3
dc.relation.volume19
dc.type.versionacceptedVersion
dc.rights.copyright© 2010 Osteoarthritis Research Society International
dc.rights.accesslevelopenAccessfi
dc.subject.ysonivelrikko
dc.subject.ysoperinnöllisyystiede
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p12334
jyx.subject.urihttp://www.yso.fi/onto/yso/p5147
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.joca.2010.10.027


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