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dc.contributor.authorStenholm, Sari
dc.contributor.authorAlley, D
dc.contributor.authorBandinelli, S
dc.contributor.authorGriswold, ME
dc.contributor.authorKoskinen, Seppo
dc.contributor.authorRantanen, Taina
dc.contributor.authorGuralnik, Jack M
dc.contributor.authorFerrucci, Luigi
dc.date.accessioned2019-09-23T10:21:17Z
dc.date.available2019-09-23T10:21:17Z
dc.date.issued2009
dc.identifier.citationStenholm, S., Alley, D., Bandinelli, S., Griswold, M., Koskinen, S., Rantanen, T., Guralnik, J. M., & Ferrucci, L. (2009). The effect of obesity combined with low muscle strengthon decline in mobility in older persons - Results from the InCHIANTI Study. <i>International Journal of Obesity</i>, <i>33</i>(6), 635-644.
dc.identifier.otherCONVID_20292017
dc.identifier.otherTUTKAID_44983
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65609
dc.description.abstractObjective: Both obesity and muscle impairment are increasingly prevalent among older persons and negatively affect health and physical functioning. However, the combined effect of coexisting obesity and muscle impairment on physical function decline has been little studied. We examined whether obese persons with low muscle strength experience significantly greater declines in walking speed and mobility than persons with only obesity or low muscle strength. Design: Community-dwelling adults aged ⩾65 years (n=930) living in the Chianti geographic area (Tuscany, Italy) were followed for 6 years in the population-based InCHIANTI study. Measurements: On the basis of baseline measurements (1998–2000), obesity was defined as body mass index (BMI) ⩾30 kg/m2 and low muscle strength as lowest sex-specific tertile of knee extensor strength. Walking speed and self-reported mobility disability (ability to walk 400 m or climb one flight of stairs) were assessed at baseline and at 3- and 6-year follow-up. Results: At baseline, obese persons with low muscle strength had significantly lower walking speed compared with all other groups (P⩽0.05). In longitudinal analyses, obese participants with low muscle strength had steeper decline in walking speed and high risk of developing new mobility disability over the 6-year follow-up compared with those without obesity or low muscle strength. After the age of 80, the differences between groups were substantially attenuated. The differences seen in walking speed across combination of low muscle strength and obesity groups were partly explained by 6-year changes in muscle strength, BMI and waist circumference. Conclusions: Obesity combined with low muscle strength increases the risk of decline in walking speed and developing mobility disability, especially among persons <80 years old.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Pub. Group
dc.relation.ispartofseriesInternational Journal of Obesity
dc.rightsIn Copyright
dc.subject.otheraging
dc.subject.othermuscle strength decline
dc.titleThe effect of obesity combined with low muscle strengthon decline in mobility in older persons - Results from the InCHIANTI Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909114122
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-09-11T12:15:56Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange635-644
dc.relation.issn0307-0565
dc.relation.numberinseries6
dc.relation.volume33
dc.type.versionacceptedVersion
dc.rights.copyright© 2009 Springer Nature
dc.rights.accesslevelopenAccessfi
dc.subject.ysoikääntyminen
dc.subject.ysovanheneminen
dc.subject.ysolihavuus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p470
jyx.subject.urihttp://www.yso.fi/onto/yso/p823
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en


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