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dc.contributor.authorLoth, Daan W
dc.contributor.authorArtigas, María Soler
dc.contributor.authorGharib, Sina A
dc.contributor.authorWain, Louise V
dc.contributor.authorFranceschini, Nora
dc.contributor.authorKoch, Beate
dc.contributor.authorPottinger, Tess D
dc.contributor.authorSmith, Albert Vernon
dc.contributor.authorDuan, Qing
dc.contributor.authorOldmeadow, Chris
dc.contributor.authorLee, Mi Kyeong
dc.contributor.authorStrachan, David P
dc.contributor.authorJames, Alan L
dc.contributor.authorHuffman, Jennifer E
dc.contributor.authorVitart, Veronique
dc.contributor.authorRamasamy, Adaikalavan
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorWang, Xin-Qun
dc.contributor.authorTrochet, Holly
dc.contributor.authorKähönen, Mika
dc.contributor.authorFlexeder, Claudia
dc.contributor.authorAlbrecht, Eva
dc.contributor.authorLopez, Lorna M
dc.contributor.authorJong, Kim de
dc.contributor.authorRantanen, Taina
dc.date.accessioned2019-09-18T12:16:14Z
dc.date.available2019-09-18T12:16:14Z
dc.date.issued2014fi
dc.identifier.citationLoth, D. W., Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., . . . Rantanen, T. (2014). Genome-wide association analysis identifies six new loci associated with forced vital capacity. <em>Nature Genetics</em>, 46 (7), 669-677. <a href="https://doi.org/10.1038/ng.3011">doi:10.1038/ng.3011</a>fi
dc.identifier.otherTUTKAID_62191
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65560
dc.description.abstractForced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10−8) with FVC in or near EFEMP1, BMP6, MIR129-2–HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesNature Genetics
dc.rightsIn Copyright
dc.subject.otheridiopathic pulmonary-fibrosisfi
dc.subject.otherlung-function, gene-expressionfi
dc.titleGenome-wide association analysis identifies six new loci associated with forced vital capacityfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909184198
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-09-18T09:15:24Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange669 677
dc.relation.issn1061-4036
dc.relation.numberinseries7
dc.relation.volume46
dc.type.versionacceptedVersion
dc.rights.copyright© 2014, Springer Nature
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1038/ng.3011


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