dc.contributor.author | Hebelka, H. | |
dc.contributor.author | Lagerstrand, K. | |
dc.contributor.author | Brisby, H. | |
dc.contributor.author | Owen, P. J. | |
dc.contributor.author | Quittner, M. J. | |
dc.contributor.author | Rantalainen, T. | |
dc.contributor.author | Belavy, D. L. | |
dc.date.accessioned | 2019-09-06T04:41:21Z | |
dc.date.available | 2019-09-06T04:41:21Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Hebelka, H., Lagerstrand, K., Brisby, H., Owen, P. J., Quittner, M. J., Rantalainen, T., & Belavy, D. L. (2019). The importance of level stratification for quantitative MR studies of lumbar intervertebral discs : a cross-sectional analysis in 101 healthy adults. <i>European Spine Journal</i>, <i>28</i>(9), 2153-2161. <a href="https://doi.org/10.1007/s00586-019-06059-1" target="_blank">https://doi.org/10.1007/s00586-019-06059-1</a> | |
dc.identifier.other | CONVID_32138621 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/65427 | |
dc.description.abstract | Purpose: To investigate whether quantitative T2-times depend on lumbar intervertebral disc (IVD) level.
Methods: The lumbar spine (Th12/L1–L5/S1) of 101 participants (53.5% female, 30.0[± 3.6]years, 173.5[± 9.6]cm and 69.9[± 13.4]kg), without history of back pain, was examined on a 3T scanner with sagittal T2-mapping. All IVDs were stratified according to Pfirrmann grade and lumbar level, with mean T2-time determined for the entire IVD volume and in five subregions of interests.
Results: Significant level-dependent T2-time differences were detected, both for the entire IVD volume and its subregions. For the entire IVD volume, Pfirrmann grade 2 IVDs displayed 9–18% higher T2-times in Th12/L1 IVDs compared to L2/L3–L5/S1 IVDs (0.001 > p < 0.004) and significantly different T2-times in L1/L2–L2/L3 IVDs compared to most of the IVDs in the lower lumbar spine. In Pfirrmann grades 1, 3 and 4 IVDs, no significant level-dependent T2-time differences were observed for the entire IVD. More pronounced results were observed when comparing IVD subregions, with significant level-dependent differences also within Pfirrmann grade 1 and grade 3 IVDs. For example, in posterior IVD subregions mean T2-time was 80–82% higher in Th12/L1 compared to L3/L4–L4/L5 Pfirrmann grade 1 IVDs (p < 0.05) and 10–14% higher in L5/S1 compared to L3/L4–L4/L5 Pfirrmann grade 3 IVDs (0.02 > p < 0.001).
Discussion: Significant level-dependent T2-time differences within several Pfirrmann grades, both for the entire IVD volume and for multiple IVD subregions, were shown in this large cohort study. The T2-time differences between levels existed in both non-degenerated and degenerated IVDs. These findings show the importance of stratifying for lumbar level when quantitative IVD studies are performed using T2-mapping. | en |
dc.format.mimetype | application/pdf | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartofseries | European Spine Journal | |
dc.rights | CC BY 4.0 | |
dc.subject.other | T2 mapping | |
dc.subject.other | magnetic resonance imaging | |
dc.subject.other | quantitative MRI | |
dc.subject.other | intervertebral disc | |
dc.subject.other | lumbar level | |
dc.title | The importance of level stratification for quantitative MR studies of lumbar intervertebral discs : a cross-sectional analysis in 101 healthy adults | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201909064028 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Gerontologian tutkimuskeskus | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.contributor.oppiaine | Gerontology Research Center | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 2153-2161 | |
dc.relation.issn | 0940-6719 | |
dc.relation.numberinseries | 9 | |
dc.relation.volume | 28 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © The Author(s) 2019 | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | lanneranka | |
dc.subject.yso | magneettikuvaus | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5598 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p12131 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1007/s00586-019-06059-1 | |
jyx.fundinginformation | Open access funding provided by University of Gothenburg. This project was supported by the School of Exercise and Nutrition Sciences, Deakin University (Grant ID: Belavy 2014-2017). The study was also financed by grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement ALFGBG-792231. | |
dc.type.okm | A1 | |