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dc.contributor.authorHebelka, H.
dc.contributor.authorLagerstrand, K.
dc.contributor.authorBrisby, H.
dc.contributor.authorOwen, P. J.
dc.contributor.authorQuittner, M. J.
dc.contributor.authorRantalainen, T.
dc.contributor.authorBelavy, D. L.
dc.date.accessioned2019-09-06T04:41:21Z
dc.date.available2019-09-06T04:41:21Z
dc.date.issued2019
dc.identifier.citationHebelka, H., Lagerstrand, K., Brisby, H., Owen, P. J., Quittner, M. J., Rantalainen, T., & Belavy, D. L. (2019). The importance of level stratification for quantitative MR studies of lumbar intervertebral discs : a cross-sectional analysis in 101 healthy adults. <i>European Spine Journal</i>, <i>28</i>(9), 2153-2161. <a href="https://doi.org/10.1007/s00586-019-06059-1" target="_blank">https://doi.org/10.1007/s00586-019-06059-1</a>
dc.identifier.otherCONVID_32138621
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65427
dc.description.abstractPurpose: To investigate whether quantitative T2-times depend on lumbar intervertebral disc (IVD) level. Methods: The lumbar spine (Th12/L1–L5/S1) of 101 participants (53.5% female, 30.0[± 3.6]years, 173.5[± 9.6]cm and 69.9[± 13.4]kg), without history of back pain, was examined on a 3T scanner with sagittal T2-mapping. All IVDs were stratified according to Pfirrmann grade and lumbar level, with mean T2-time determined for the entire IVD volume and in five subregions of interests. Results: Significant level-dependent T2-time differences were detected, both for the entire IVD volume and its subregions. For the entire IVD volume, Pfirrmann grade 2 IVDs displayed 9–18% higher T2-times in Th12/L1 IVDs compared to L2/L3–L5/S1 IVDs (0.001 > p < 0.004) and significantly different T2-times in L1/L2–L2/L3 IVDs compared to most of the IVDs in the lower lumbar spine. In Pfirrmann grades 1, 3 and 4 IVDs, no significant level-dependent T2-time differences were observed for the entire IVD. More pronounced results were observed when comparing IVD subregions, with significant level-dependent differences also within Pfirrmann grade 1 and grade 3 IVDs. For example, in posterior IVD subregions mean T2-time was 80–82% higher in Th12/L1 compared to L3/L4–L4/L5 Pfirrmann grade 1 IVDs (p < 0.05) and 10–14% higher in L5/S1 compared to L3/L4–L4/L5 Pfirrmann grade 3 IVDs (0.02 > p < 0.001). Discussion: Significant level-dependent T2-time differences within several Pfirrmann grades, both for the entire IVD volume and for multiple IVD subregions, were shown in this large cohort study. The T2-time differences between levels existed in both non-degenerated and degenerated IVDs. These findings show the importance of stratifying for lumbar level when quantitative IVD studies are performed using T2-mapping.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesEuropean Spine Journal
dc.rightsCC BY 4.0
dc.subject.otherT2 mapping
dc.subject.othermagnetic resonance imaging
dc.subject.otherquantitative MRI
dc.subject.otherintervertebral disc
dc.subject.otherlumbar level
dc.titleThe importance of level stratification for quantitative MR studies of lumbar intervertebral discs : a cross-sectional analysis in 101 healthy adults
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909064028
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2153-2161
dc.relation.issn0940-6719
dc.relation.numberinseries9
dc.relation.volume28
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2019
dc.rights.accesslevelopenAccessfi
dc.subject.ysolanneranka
dc.subject.ysomagneettikuvaus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5598
jyx.subject.urihttp://www.yso.fi/onto/yso/p12131
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s00586-019-06059-1
jyx.fundinginformationOpen access funding provided by University of Gothenburg. This project was supported by the School of Exercise and Nutrition Sciences, Deakin University (Grant ID: Belavy 2014-2017). The study was also financed by grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement ALFGBG-792231.


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