Breathe out and learn : Expiration-contingent stimulus presentation facilitates associative learning in trace eyeblink conditioning
Waselius, T., Wikgren, J., Penttonen, M., & Nokia, M. (2019). Breathe out and learn : Expiration-contingent stimulus presentation facilitates associative learning in trace eyeblink conditioning. Psychophysiology, 56(9), Article e13387. https://doi.org/10.1111/psyp.13387
DisciplinePsykologiaMonitieteinen aivotutkimuskeskusPsychologyCentre for Interdisciplinary Brain Research
© 2019 Society for Psychophysiological Research
Rhythmic variation in heart rate and respiratory pattern are coupled in a way that optimizes the level of oxygen in the blood stream of the lungs and the body as well as saves energy in pulmonary gas exchange. It has been suggested that the cardiac cycle and respiratory pattern are coupled to neural oscillations of the brain. Yet, studies on how this rhythmic coupling is related to behavior are scarce. There is some evidence that, for example, the phase of respiration affects memory retrieval and the electrophysiological oscillatory state of the limbic system. It is also known that the phase of the cardiac cycle and hippocampal electrophysiological oscillations alone affect learning. Here, we studied whether the timing of training trials to different phases of respiration affects learning trace eyeblink conditioning in healthy adult humans. Trials consisting of a neutral conditioned stimulus (200‐ms tone) and a slightly aversive unconditioned stimulus (100‐ms air puff toward the eye), presented with a 600‐ms trace interval, were timed to either inspiration or expiration. A control group was trained regardless of respiratory phase. We found that, at the end of training, the rate of conditioned responses was higher in the group trained at expiration than it was in the other two groups. That is, brain state seems to fluctuate as a function of respiratory rhythm, and this fluctuation is also behaviorally relevant, exerting its effect on, at the least, a simple form of associative learning. ...
PublisherWiley-Blackwell Publishing, Inc.
Publication in research information system
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Related funder(s)Academy of Finland
Funding program(s)Academy Project, AoF
Additional information about fundingSuomen Akatemia. Grant Number: 286384
Showing items with similar title or keywords.
Cardiac cycle and respiration phase affect responses to the conditioned stimulus in young adults trained in trace eyeblink conditioning Waselius, Tomi; Xu, Weiyong; Sparre, Julia Isabella; Penttonen, Markku; Nokia, Miriam S. (American Physiological Society, 2022)Rhythms of breathing and heartbeat are linked to each other as well as to rhythms of the brain. Our recent studies suggest that presenting the conditioned stimulus during expiration or during the diastolic phase of the ...
Waselius, Tomi; Pöllänen, Eveliina; Wikgren, Jan; Penttonen, Markku; Nokia, Miriam (Elsevier BV, 2017)Hippocampal theta oscillations (3–12 Hz) play a prominent role in learning. It has been suggested that encoding and retrieval of memories are supported by different phases of the theta cycle. Our previous study on trace ...
Nokia, Miriam (University of Jyväskylä, 2009)
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