dc.contributor.author | Borges, Iara | |
dc.contributor.author | Rodrigues, Rodrigo Araújo Lima | |
dc.contributor.author | Dornas, Fábio Pio | |
dc.contributor.author | De Freitas Almeida, Gabriel | |
dc.contributor.author | Aquino, Isabella | |
dc.contributor.author | Bonjardim, Cláudio Antônio | |
dc.contributor.author | Kroon, Erna Geessien | |
dc.contributor.author | Scola, Bernard La | |
dc.contributor.author | Abrahão, Jônatas Santos | |
dc.date.accessioned | 2019-07-15T09:31:05Z | |
dc.date.available | 2020-01-01T22:35:37Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Borges, I., Rodrigues, R. A. L., Dornas, F. P., De Freitas Almeida, G., Aquino, I., Bonjardim, C. A., Kroon, E. G., Scola, B. L., & Abrahão, J. S. (2019). Trapping the enemy : Vermamoeba vermiformis circumvents Faustovirus mariensis dissemination by enclosing viral progeny inside cysts. <i>Journal of Virology</i>, <i>93</i>(14), Article e00312-19. <a href="https://doi.org/10.1128/JVI.00312-19" target="_blank">https://doi.org/10.1128/JVI.00312-19</a> | |
dc.identifier.other | CONVID_30614768 | |
dc.identifier.other | TUTKAID_81379 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/65063 | |
dc.description.abstract | Viruses depend on cells to replicate and can cause considerable damage to their hosts. However, hosts have developed a plethora of antiviral mechanisms to counterattack or prevent viral replication and to maintain homeostasis. Advantageous features are constantly being selected, affecting host-virus interactions
and constituting a harsh race for supremacy in nature. Here, we describe a new antiviral mechanism unveiled by the interaction between a giant virus and its amoebal
host. Faustovirus mariensis infects Vermamoeba vermiformis, a free-living amoeba,
and induces cell lysis to disseminate into the environment. Once infected, the cells
release a soluble factor that triggers the encystment of neighbor cells, preventing
their infection. Remarkably, infected cells stimulated by the factor encyst and trap
the viruses and viral factories inside cyst walls, which are no longer viable and cannot excyst. This unprecedented mechanism illustrates that a plethora of antiviral
strategies remains to be discovered in nature | fi |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | American Society for Microbiology | |
dc.relation.ispartofseries | Journal of Virology | |
dc.rights | In Copyright | |
dc.subject.other | Faustovirus | |
dc.subject.other | amoeba | |
dc.subject.other | antiviral mechanisms | |
dc.subject.other | Vermamoeba vermiformis | |
dc.title | Trapping the enemy : Vermamoeba vermiformis circumvents Faustovirus mariensis dissemination by enclosing viral progeny inside cysts | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201907083596 | |
dc.contributor.laitos | Bio- ja ympäristötieteiden laitos | fi |
dc.contributor.laitos | Department of Biological and Environmental Science | en |
dc.contributor.oppiaine | Solu- ja molekyylibiologia | fi |
dc.contributor.oppiaine | Cell and Molecular Biology | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2019-07-08T12:15:09Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.relation.issn | 0022-538X | |
dc.relation.numberinseries | 14 | |
dc.relation.volume | 93 | |
dc.type.version | acceptedVersion | |
dc.rights.copyright | © 2019 American Society for Microbiology | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | infektiot | |
dc.subject.yso | virukset | |
dc.subject.yso | amebat | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p7316 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p1123 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p21414 | |
dc.rights.url | http://rightsstatements.org/page/InC/1.0/?language=en | |
dc.relation.doi | 10.1128/JVI.00312-19 | |
jyx.fundinginformation | In addition, we acknowledge the financial support from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa do estado de Minas Gerais (FAPEMIG), and the Ministério da Saúde (MS-DECIT). | |
dc.type.okm | A1 | |