Trapping the enemy : Vermamoeba vermiformis circumvents Faustovirus mariensis dissemination by enclosing viral progeny inside cysts
Borges, I., Rodrigues, R. A. L., Dornas, F. P., De Freitas Almeida, G., Aquino, I., Bonjardim, C. A., Kroon, E. G., Scola, B. L., & Abrahão, J. S. (2019). Trapping the enemy : Vermamoeba vermiformis circumvents Faustovirus mariensis dissemination by enclosing viral progeny inside cysts. Journal of Virology, 93(14), Article e00312-19. https://doi.org/10.1128/JVI.00312-19
Published inJournal of Virology
© 2019 American Society for Microbiology
Viruses depend on cells to replicate and can cause considerable damage to their hosts. However, hosts have developed a plethora of antiviral mechanisms to counterattack or prevent viral replication and to maintain homeostasis. Advantageous features are constantly being selected, affecting host-virus interactions and constituting a harsh race for supremacy in nature. Here, we describe a new antiviral mechanism unveiled by the interaction between a giant virus and its amoebal host. Faustovirus mariensis infects Vermamoeba vermiformis, a free-living amoeba, and induces cell lysis to disseminate into the environment. Once infected, the cells release a soluble factor that triggers the encystment of neighbor cells, preventing their infection. Remarkably, infected cells stimulated by the factor encyst and trap the viruses and viral factories inside cyst walls, which are no longer viable and cannot excyst. This unprecedented mechanism illustrates that a plethora of antiviral strategies remains to be discovered in nature ...
PublisherAmerican Society for Microbiology
Publication in research information system
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Additional information about fundingIn addition, we acknowledge the financial support from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa do estado de Minas Gerais (FAPEMIG), and the Ministério da Saúde (MS-DECIT).
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