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dc.contributor.authorSainio, Annele
dc.contributor.authorPennanen, Mirka
dc.contributor.authorLaine, Jukka
dc.contributor.authorLund, Riikka
dc.contributor.authorSöderström, Mirva
dc.contributor.authorKuopio, Teijo
dc.contributor.authorJärveläinen, Hannu
dc.date.accessioned2019-06-24T08:33:32Z
dc.date.available2019-06-24T08:33:32Z
dc.date.issued2019
dc.identifier.citationSainio, A., Pennanen, M., Laine, J., Lund, R., Söderström, M., Kuopio, T., & Järveläinen, H. (2019). Decorin Expression and Oncosuppression in Human Embryonic Carcinomas. <i>Archives of Clinical and Medical Case Reports</i>, <i>3</i>(4), 140-152. <a href="https://doi.org/10.26502/acmcr.96550072" target="_blank">https://doi.org/10.26502/acmcr.96550072</a>
dc.identifier.otherCONVID_31218324
dc.identifier.otherTUTKAID_81683
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/64791
dc.description.abstractHuman embryonic stem cells in culture can transform into malignant, cancer-like cells exhibiting lesser differentiation. After transplantation, these transformed cells can form highly malignant germ cell tumors. In humans, germ cell tumors often appear at gonadal sites, like in the testis. In this study, we examined the expression of small leucine rich proteoglycans in normal and karyotypically abnormal human embryonic stem cells using a publicly available transcriptome data. We also examined the expression of the small leucine rich proteoglycans in healthy human testis and in different human testicular non-seminoma germ cell tumors using IST Online database. Furthermore, we localized the expression of decorin, the prototype member of the small leucine rich proteoglycans, in samples representing the above testicular tissues, using in situ hybridization and immunohistochemistry. The analysis revealed that the expression of two small leucine rich proteoglycans, namely decorin and lumican, was induced in normal but not in karyotypically abnormal human embryonic stem cells during early cell differentiation. Similarly, in IST Online database the expression of these two small leucine rich proteoglycans was markedly higher in differentiated teratoma tissue than in undifferentiated embryonal carcinoma tissue. In testicular germ cell tumors decorin expression was completely lacking in the areas of undifferentiated malignant cells. The above results collectively suggest that decorin and lumican have a role in human stem cell differentiation and testicular non-seminoma germ cell tumor formation.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherFortune Journals
dc.relation.ispartofseriesArchives of Clinical and Medical Case Reports
dc.rightsCC BY 4.0
dc.subject.otherproteoglycan
dc.subject.otherstem cell
dc.subject.otherteratoma
dc.subject.otherembryonal carcinoma
dc.subject.otherin situ hybridization
dc.titleDecorin Expression and Oncosuppression in Human Embryonic Carcinomas
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201906243373
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-06-24T06:15:15Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange140-152
dc.relation.issn2575-9655
dc.relation.numberinseries4
dc.relation.volume3
dc.type.versionpublishedVersion
dc.rights.copyright© The Authors & Archives of Clinical and Medical Case Reports, 2019.
dc.rights.accesslevelopenAccessfi
dc.subject.ysokantasolut
dc.subject.ysosyöpäsolut
dc.subject.ysokarsinoomat
dc.subject.ysoproteiinit
dc.subject.ysosoluväliaine
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p13517
jyx.subject.urihttp://www.yso.fi/onto/yso/p23898
jyx.subject.urihttp://www.yso.fi/onto/yso/p28373
jyx.subject.urihttp://www.yso.fi/onto/yso/p4332
jyx.subject.urihttp://www.yso.fi/onto/yso/p27428
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.26502/acmcr.96550072


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