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dc.contributor.authorLaw, Philip J.
dc.contributor.authorTimofeeva, Maria
dc.contributor.authorFernandez-Rozadilla, Ceres
dc.contributor.authorBroderick, Peter
dc.contributor.authorStudd, James
dc.contributor.authorFernandez-Tajes, Juan
dc.contributor.authorFarrington, Susan
dc.contributor.authorSvinti, Victoria
dc.contributor.authorPalles, Claire
dc.contributor.authorOrlando, Giulia
dc.contributor.authorSud, Amit
dc.contributor.authorHolroyd, Amy
dc.contributor.authorPenegar, Steven
dc.contributor.authorTheodoratou, Evropi
dc.contributor.authorVaughan-Shaw, Peter
dc.contributor.authorCampbell, Harry
dc.contributor.authorZgaga, Lina
dc.contributor.authorHayward, Caroline
dc.contributor.authorCampbell, Archie
dc.contributor.authorHarris, Sarah
dc.contributor.authorDeary, Ian J.
dc.contributor.authorStarr, John
dc.contributor.authorGatcombe, Laura
dc.contributor.authorPinna, Maria
dc.contributor.authorBriggs, Sarah
dc.contributor.authorMartin, Lynn
dc.contributor.authorJaeger, Emma
dc.contributor.authorSharma-Oates, Archana
dc.contributor.authorEast, James
dc.contributor.authorLeedham, Simon
dc.contributor.authorArnold, Roland
dc.contributor.authorJohnstone, Elaine
dc.contributor.authorWang, Haitao
dc.contributor.authorKerr, David
dc.contributor.authorKerr, Rachel
dc.contributor.authorMaughan, Tim
dc.contributor.authorKaplan, Richard
dc.contributor.authorAl-Tassan, Nada
dc.contributor.authorPalin, Kimmo
dc.contributor.authorHänninen, Ulrika A.
dc.contributor.authorCajuso, Tatiana
dc.contributor.authorTanskanen, Tomas
dc.contributor.authorKondelin, Johanna
dc.contributor.authorKaasinen, Eevi
dc.contributor.authorSarin, Antti-Pekka
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorRissanen, Harri
dc.contributor.authorKnekt, Paul
dc.contributor.authorPukkala, Eero
dc.contributor.authorJousilahti, Pekka
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorRipatti, Samuli
dc.contributor.authorPalotie, Aarno
dc.contributor.authorRenkonen-Sinisalo, Laura
dc.contributor.authorLepistö, Anna
dc.contributor.authorBöhm, Jan
dc.contributor.authorMecklin, Jukka-Pekka
dc.contributor.authorBuchanan, Daniel D.
dc.contributor.authorWin, Aung-Ko
dc.contributor.authorHopper, John
dc.contributor.authorJenkins, Mark E.
dc.contributor.authorLindor, Noralane M.
dc.contributor.authorNewcomb, Polly A.
dc.contributor.authorGallinger, Steven
dc.contributor.authorDuggan, David
dc.contributor.authorCasey, Graham
dc.contributor.authorHoffmann, Per
dc.contributor.authorNöthen, Markus M.
dc.contributor.authorJöckel, Karl-Heinz
dc.contributor.authorEaston, Douglas F.
dc.contributor.authorPharoah, Paul D. P.
dc.contributor.authorPeto, Julian
dc.contributor.authorCanzian, Federico
dc.contributor.authorSwerdlow, Anthony
dc.contributor.authorEeles, Rosalind A.
dc.contributor.authorKote-Jarai, Zsofia
dc.contributor.authorMuir, Kenneth
dc.contributor.authorPashayan, Nora
dc.contributor.authorconsortium, The PRACTICAL
dc.contributor.authorHarkin, Andrea
dc.contributor.authorAllan, Karen
dc.contributor.authorMcQueen, John
dc.contributor.authorPaul, James
dc.contributor.authorIveson, Timothy
dc.contributor.authorSaunders, Mark
dc.contributor.authorButterbach, Katja
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorHoffmeister, Michael
dc.contributor.authorBrenner, Hermann
dc.contributor.authorKirac, Iva
dc.contributor.authorMatošević, Petar
dc.contributor.authorHofer, Philipp
dc.contributor.authorBrezina, Stefanie
dc.contributor.authorGsur, Andrea
dc.contributor.authorCheadle, Jeremy P.
dc.contributor.authorAaltonen, Lauri A.
dc.contributor.authorTomlinson, Ian
dc.contributor.authorHoulston, Richard S.
dc.contributor.authorDunlop, Malcolm G.
dc.date.accessioned2019-05-20T06:40:00Z
dc.date.available2019-05-20T06:40:00Z
dc.date.issued2019
dc.identifier.citationLaw, P. J., Timofeeva, M., Fernandez-Rozadilla, C., Broderick, P., Studd, J., Fernandez-Tajes, J., Farrington, S., Svinti, V., Palles, C., Orlando, G., Sud, A., Holroyd, A., Penegar, S., Theodoratou, E., Vaughan-Shaw, P., Campbell, H., Zgaga, L., Hayward, C., Campbell, A., . . . Dunlop, M. G. (2019). Association analyses identify 31 new risk loci for colorectal cancer susceptibility. <i>Nature Communications</i>, <i>10</i>, Article 2154. <a href="https://doi.org/10.1038/s41467-019-09775-w" target="_blank">https://doi.org/10.1038/s41467-019-09775-w</a>
dc.identifier.otherCONVID_30675956
dc.identifier.otherTUTKAID_81447
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/64054
dc.description.abstractColorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesNature Communications
dc.rightsCC BY 4.0
dc.subject.othercancer genetics
dc.subject.othercancer genomics
dc.subject.othercolorectal cancer
dc.subject.othergenome-wide association studies
dc.titleAssociation analyses identify 31 new risk loci for colorectal cancer susceptibility
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201905152623
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-05-15T12:15:22Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2041-1723
dc.relation.numberinseries0
dc.relation.volume10
dc.type.versionpublishedVersion
dc.rights.copyright© The Authors, 2019.
dc.rights.accesslevelopenAccessfi
dc.subject.ysosyöpätaudit
dc.subject.ysosyöpägeenit
dc.subject.ysogenomiikka
dc.subject.ysoperäsuolisyöpä
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p678
jyx.subject.urihttp://www.yso.fi/onto/yso/p23580
jyx.subject.urihttp://www.yso.fi/onto/yso/p5146
jyx.subject.urihttp://www.yso.fi/onto/yso/p5936
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41467-019-09775-w
dc.type.okmA1


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