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dc.contributor.authorKumar, A. Sunil
dc.contributor.authorKudva, Jyothi
dc.contributor.authorLahtinen, Manu
dc.contributor.authorPeuronen, Anssi
dc.contributor.authorSadashiva, Rajitha
dc.contributor.authorNaral, Damodara
dc.date.accessioned2019-04-25T06:31:29Z
dc.date.available2021-08-16T21:35:07Z
dc.date.issued2019
dc.identifier.citationKumar, A. S., Kudva, J., Lahtinen, M., Peuronen, A., Sadashiva, R., & Naral, D. (2019). Synthesis, characterization, crystal structures and biological screening of 4-amino quinazoline sulfonamide derivatives. <i>Journal of Molecular Structure</i>, <i>1190</i>, 29-36. <a href="https://doi.org/10.1016/j.molstruc.2019.04.050" target="_blank">https://doi.org/10.1016/j.molstruc.2019.04.050</a>
dc.identifier.otherCONVID_30121675
dc.identifier.otherTUTKAID_81228
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63609
dc.description.abstractThree quinazolin-4-ylamino derivatives containing phenylbenzenesulfonamides (7a-7c) were synthesized by reacting (E)-N'-(2-cyanophenyl)-N,N-dimethyl formamidine (6) with different 4- amino-N-(phenyl)benzenesulfonamides (4a-4c) and characterized by different techniques such as HRMS, IR, 1H NMR and 13C NMR spectroscopy. The structural properties were further examined by single crystal X-ray diffraction method. The X-ray data shows that compounds 7a and 7c contain two molecules and 7b contains one molecule in the asymmetric unit. Comparison of conformation of two distinct molecules, “A” and “B”, in the asymmetric unit of 7a and 7c were studied with the aid of reported literature. The in vitro antiproliferative activity of the compounds was tested against two breast cancer cell lines (MDA-MB-231 and MCF7). Compound 7b observed as a highest potent candidate against MDA-MB-231with IC50 of 5.44 µg/mL. Antimicrobial activity was also screened against bacterial and fungal strains. Compound 7a with chloro substitution was observed as the most potent candidate against the Gram-negative bacterial strains, whereas the compounds showed no significant activity against the fungal strain.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofseriesJournal of Molecular Structure
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherX-ray-diffraction
dc.subject.otherquinazoline-sulfonamide
dc.subject.othercrystal structure
dc.subject.otherantimicrobial
dc.subject.otherantiproliferative activity
dc.titleSynthesis, characterization, crystal structures and biological screening of 4-amino quinazoline sulfonamide derivatives
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201904232241
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineEpäorgaaninen ja analyyttinen kemiafi
dc.contributor.oppiaineInorganic and Analytical Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-04-23T09:15:28Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange29-36
dc.relation.issn0022-2860
dc.relation.numberinseries0
dc.relation.volume1190
dc.type.versionacceptedVersion
dc.rights.copyright©2019 Published by Elsevier B.V.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber277250
dc.subject.ysoaromaattiset yhdisteet
dc.subject.ysoantimikrobiset yhdisteet
dc.subject.ysokemiallinen synteesi
dc.subject.ysosolunsalpaajat
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23502
jyx.subject.urihttp://www.yso.fi/onto/yso/p21949
jyx.subject.urihttp://www.yso.fi/onto/yso/p8468
jyx.subject.urihttp://www.yso.fi/onto/yso/p9995
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.molstruc.2019.04.050
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationThe authors are gratefully acknowledge the financial support provided by VGST-K-FIST (L1)/2017, GRD No. 557 and the Academy of Finland (Project No. 277250 and 315911).


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