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dc.contributor.authorCollins, Brittany C.
dc.contributor.authorLaakkonen, Eija
dc.contributor.authorLowe, Dawn A.
dc.date.accessioned2019-04-15T10:22:34Z
dc.date.issued2019fi
dc.identifier.citationCollins, B. C., Laakkonen, E., & Lowe, D. A. (2019). Aging of the musculoskeletal system : How the loss of estrogen impacts muscle strength. <em>Bone</em>, 123, 137-144. <a href="https://doi.org/10.1016/j.bone.2019.03.033">doi:10.1016/j.bone.2019.03.033</a>fi
dc.identifier.otherTUTKAID_81112
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63498
dc.description.abstractSkeletal muscle weakness occurs with aging and in females this is compounded by the loss of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle strength from both inadequate preservation of skeletal muscle mass and decrements in the quality of the remaining skeletal muscle. Processes and components of skeletal muscle that are affected by estrogens are beginning to be identified. This review focuses on mechanisms that contribute to the loss of muscle force generation when estrogen is low in females, and conversely the maintenance of strength by estrogen. Evidence is accumulating that estrogen deficiency induces apoptosis in skeletal muscle contributing to loss of mass and thus strength. Estrogen sensitive processes that affect quality, i.e., force generating capacity of muscle, include myosin phosphorylation and satellite cell function. Further detailing these mechanisms and identifying additional mechanisms that underlie estrogenic effects on skeletal muscle is important foundation for the design of therapeutic strategies to minimize skeletal muscle pathologies, such as sarcopenia and dynapenia.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier Inc.
dc.relation.ispartofseriesBone
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherikääntyminenfi
dc.subject.otherestrogeenitfi
dc.subject.otherlihasvoimafi
dc.subject.otheragingfi
dc.subject.otherestrogenfi
dc.subject.otherskeletal musclefi
dc.subject.otherstrengthfi
dc.titleAging of the musculoskeletal system : How the loss of estrogen impacts muscle strengthfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201904112158
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.date.embargo2020-06-01
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-04-11T15:15:05Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange137-144
dc.relation.issn8756-3282
dc.relation.numberinseries0
dc.relation.volume123
dc.type.versionFinal Draft
dc.rights.copyright© 2019 Elsevier Inc.
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.bone.2019.03.033


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Except where otherwise noted, this item's license is described as CC BY-NC-ND 4.0