Show simple item record

dc.contributor.authorNoortman, Laurien C. M.
dc.contributor.authorHaapala, Eero
dc.contributor.authorTakken, Tim
dc.date.accessioned2019-04-09T12:24:42Z
dc.date.available2019-04-09T12:24:42Z
dc.date.issued2019
dc.identifier.citationNoortman, L. C. M., Haapala, E., & Takken, T. (2019). Arterial Stiffness and Its Relationship to Cardiorespiratory Fitness in Children and Young Adults with a Fontan Circulation. <i>Pediatric Cardiology</i>, <i>40</i>(4), 784-791. <a href="https://doi.org/10.1007/s00246-019-02065-8" target="_blank">https://doi.org/10.1007/s00246-019-02065-8</a>
dc.identifier.otherCONVID_28924960
dc.identifier.otherTUTKAID_80682
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63439
dc.description.abstractThere are no previous studies on arterial stiffness and its associations with cardiorespiratory fitness in young Fontan patients. Therefore, we examined the arterial stiffness and its relationship to cardiorespiratory fitness in children and young adults with a Fontan circulation. Altogether, 17 Fontan patients and 26 healthy controls (16 females and 27 males aged 8–40 years) participated in this cross-sectional study. The cardiorespiratory fitness was assessed by cardiopulmonary exercise testing on a cycle ergometer and was defined as the standard deviation scores (SDS) of peak oxygen uptake per body mass (VO2peak/kg) based on the national reference values and assessed with cardiopulmonary exercise testing on a cycle ergometer. Aortic pulse wave velocity (PWVao) as a measure of arterial stiffness and aortic Augmentation Index (AIX) as a measure of peripheral arterial tone, were assessed by non-invasive oscillometric device from upper arm. Body adiposity was determined by body mass index SDS and the sport participation by interview. Data were analyzed using linear regression analyses and Pearson’s correlations, adjusted for age and sex. Fontan patients had a lower VO2peak/kg-SDS (− 2.69 vs 0.078), higher PWVao-SDS (1.13 vs − 0.24) and higher AIX (19.26% vs 8.49%) in comparison with healthy controls. PWVao and AIX were negatively associated with VO2peak/kg (standard regression coefficient (β) − 0.525, 95% confidence interval (CI) − 0.722 to − 0.227, p < 0.01 and β − 0.371, 95% CI − 0.672 to − 0.080, p = 0.014). Young Fontan patients have the arterial stiffness of healthy people who are twice as old. Thereby, children and young adults with a Fontan circulation have a lower cardiorespiratory fitness and less sport participation. Arterial stiffness is inversely associated with cardiorespiratory fitness and exercise training might be an intervention to improve vascular health in this population.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer New York LLC
dc.relation.ispartofseriesPediatric Cardiology
dc.rightsCC BY 4.0
dc.subject.otherarterial stiffness
dc.subject.othercardiorespiratory fitness
dc.subject.otherfontan circulation
dc.subject.otheruniventricular heart
dc.subject.otherpulse wave velocity
dc.subject.otheraugmentation index
dc.titleArterial Stiffness and Its Relationship to Cardiorespiratory Fitness in Children and Young Adults with a Fontan Circulation
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201904082100
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-04-08T12:15:35Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange784-791
dc.relation.issn0172-0643
dc.relation.numberinseries4
dc.relation.volume40
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2019
dc.rights.accesslevelopenAccessfi
dc.subject.ysosynnynnäiset sydänviat
dc.subject.ysofyysinen kunto
dc.subject.ysolapset (ikäryhmät)
dc.subject.ysonuoret
dc.subject.ysonuoret aikuiset
dc.subject.ysonuoruus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p9888
jyx.subject.urihttp://www.yso.fi/onto/yso/p7384
jyx.subject.urihttp://www.yso.fi/onto/yso/p4354
jyx.subject.urihttp://www.yso.fi/onto/yso/p11617
jyx.subject.urihttp://www.yso.fi/onto/yso/p15979
jyx.subject.urihttp://www.yso.fi/onto/yso/p15327
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s00246-019-02065-8


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0