Arterial Stiffness and Its Relationship to Cardiorespiratory Fitness in Children and Young Adults with a Fontan Circulation
Noortman, L. C. M., Haapala, E., & Takken, T. (2019). Arterial Stiffness and Its Relationship to Cardiorespiratory Fitness in Children and Young Adults with a Fontan Circulation. Pediatric Cardiology, 40(4), 784-791. https://doi.org/10.1007/s00246-019-02065-8
Published inPediatric Cardiology
© The Author(s) 2019
There are no previous studies on arterial stiffness and its associations with cardiorespiratory fitness in young Fontan patients. Therefore, we examined the arterial stiffness and its relationship to cardiorespiratory fitness in children and young adults with a Fontan circulation. Altogether, 17 Fontan patients and 26 healthy controls (16 females and 27 males aged 8–40 years) participated in this cross-sectional study. The cardiorespiratory fitness was assessed by cardiopulmonary exercise testing on a cycle ergometer and was defined as the standard deviation scores (SDS) of peak oxygen uptake per body mass (VO2peak/kg) based on the national reference values and assessed with cardiopulmonary exercise testing on a cycle ergometer. Aortic pulse wave velocity (PWVao) as a measure of arterial stiffness and aortic Augmentation Index (AIX) as a measure of peripheral arterial tone, were assessed by non-invasive oscillometric device from upper arm. Body adiposity was determined by body mass index SDS and the sport participation by interview. Data were analyzed using linear regression analyses and Pearson’s correlations, adjusted for age and sex. Fontan patients had a lower VO2peak/kg-SDS (− 2.69 vs 0.078), higher PWVao-SDS (1.13 vs − 0.24) and higher AIX (19.26% vs 8.49%) in comparison with healthy controls. PWVao and AIX were negatively associated with VO2peak/kg (standard regression coefficient (β) − 0.525, 95% confidence interval (CI) − 0.722 to − 0.227, p < 0.01 and β − 0.371, 95% CI − 0.672 to − 0.080, p = 0.014). Young Fontan patients have the arterial stiffness of healthy people who are twice as old. Thereby, children and young adults with a Fontan circulation have a lower cardiorespiratory fitness and less sport participation. Arterial stiffness is inversely associated with cardiorespiratory fitness and exercise training might be an intervention to improve vascular health in this population. ...
PublisherSpringer New York LLC
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Showing items with similar title or keywords.
Longitudinal associations of physical activity, sedentary time, and cardiorespiratory fitness with arterial health in children : the PANIC study Korhonen, Marika; Väistö, Juuso; Veijalainen, Aapo; Leppänen, Marja; Ekelund, Ulf; Laukkanen, Jari A.; Brage, Soren; Lintu, Niina; Haapala, Eero A.; Lakka, Timo A. (Routledge, Taylor & Francis, 2021)We investigated the longitudinal associations of physical activity (PA), sedentary time (ST), and cardiorespiratory fitness (CRF) with arterial health among children. In our primary analyses, we investigated 245 children ...
Does sports club participation contribute to physical activity among children and adolescents? : A comparison across six European countries Kokko, Sami; Martin, Leena; Geidne, Susanna; Hoye, Aurelie Van; Lane, Aoife; Meganck, Jeroen; Scheerder, Jeroen; Seghers, Jan; Villberg, Jari; Kudlacek, Michal; Badura, Petr; Mononen, Kaisu; Blomqvist, Minna; De Clercq, Bart; Koski, Pasi (Sage Publications Ltd., 2019)Aims: Insufficient physical activity (PA) is one of the largest public health challenges of our time and requires a multisectoral public-health response. PA recommendations state that all children and adolescents should ...
Associations of physical activity, sedentary time, and cardiorespiratory fitness with heart rate variability in 6- to 9-year-old children : the PANIC study Veijalainen, Aapo; Haapala, Eero A.; Väistö, Juuso; Leppänen, Marja H.; Lintu, Niina; Tompuri, Tuomo; Seppälä, Santeri; Ekelund, Ulf; Tarvainen, Mika P.; Westgate, Kate; Brage, Søren; Lakka, Timo A. (Springer, 2019)Purpose. To study the associations of physical activity (PA), sedentary time (ST), and cardiorespiratory fitness (CRF) with heart rate variability (HRV) in children. Methods. The participants were a population sample ...
Haapala, Eero A.; Wiklund, Petri; Lintu, Niina; Tompuri, Tuomo; Väistö, Juuso; Finni, Taija; Tarkka, Ina M.; Kemppainen, Titta; Barker, Alan R.; Ekelund, Ulf; Brage, Soren; Lakka, Timo A. (Lippincott Williams & Wilkins, 2020)Purpose Few studies have investigated the independent and joint associations of cardiorespiratory fitness (CRF) and body fat percentage (BF%) with insulin resistance in children. We investigated the independent and combined ...
Mediating effects of motor performance, cardiorespiratory fitness, physical activity, and sedentary behaviour on the associations of adiposity and other cardiometabolic risk factors with academic achievement in children Haapala, Eero; Lintu, Niina; Eloranta, Aino-Maija; Venäläinen, Taisa; Poikkeus, Anna-Maija; Ahonen, Timo; Lindi, Virpi; Lakka, Timo A. (Routledge, 2018)We investigated the associations of cardiometabolic risk factors with academic achievement and whether motor performance, cardiorespiratory fitness, physical activity, or sedentary behaviour mediated these associations. ...