Leisure-time physical activity and DNA methylation age : a twin study
Sillanpää, E., Ollikainen, M., Kaprio, J., Wang, X., Leskinen, T., Kujala, U., & Törmäkangas, T. (2019). Leisure-time physical activity and DNA methylation age : a twin study. Clinical Epigenetics, 11(1), Article 12. https://doi.org/10.1186/s13148-019-0613-5
Julkaistu sarjassa
Clinical EpigeneticsTekijät
Päivämäärä
2019Oppiaine
LiikuntalääketiedeGerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöSports and Exercise MedicineGerontology and Public HealthGerontology Research CenterSchool of WellbeingTekijänoikeudet
© The Author(s) 2019.
Background: Epigenetic clocks may increase our understanding on human aging and how genetic and
environmental factors regulate an individual aging process. One of the most promising clocks is Horvath’s
DNA methylation (DNAm) age. Age acceleration, i.e., discrepancy between DNAm age and chronological age,
tells us whether the person is biologically young or old compared to his/her chronological age. Several environmental
and lifestyle factors have been shown to affect life span. We investigated genetic and environmental predictors of
DNAm age in young and older monozygotic (MZ) and dizygotic (DZ) twins with a focus on leisure time physical
activity.
Results: Quantitative genetic modeling revealed that the relative contribution of non-shared environmental factors
was larger among older compared with younger twin pairs [47% (95% CI 35, 63) vs. 26% (95% CI: 19, 35), p < 0.001].
Correspondingly, genetic variation accounted for less of the variance in older [53% (95% CI 37, 65)] compared with
younger pairs [74% (95% CI 65, 82)].
We tested the hypothesis that leisure time physical activity is one of the non-shared environmental factors that affect
epigenetic aging. A co-twin control analysis with older same-sex twin pairs (seven MZ and nine DZ pairs, mean age 60.4 years)
who had persistent discordance in physical activity for 32 years according to reported/interviewed physical-activity data
showed no differences among active and inactive co-twins, DNAm age being 60.7 vs. 61.8 years, respectively [between-group
mean-difference: − 1.17 (95%CI − 3.43,1.10)]. Results from the younger cohort of twins supported findings that LTPA is not
associated with DNAm age acceleration.
Conclusions: In older subjects, a larger amount of variance in DNAm age acceleration was explained by non-shared
environmental factors compared to young individuals. However, leisure time physical activity during adult years has at
most a minor effect on DNAm age acceleration. This is consistent with recent findings that long-term leisure time
physical activity in adulthood has little effect on mortality after controlling for genetic factors.
...
Julkaisija
BioMed CentralISSN Hae Julkaisufoorumista
1868-7075Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/28880891
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Tutkijatohtori, SALisätietoja rahoituksesta
This work was supported by the Academy of Finland [260001 to ES, 213506, 265240, 263278 to JK, 251316, 286536 to TT, and 297908 to MO], EC FP5 GenomEUtwin (JK), NIH NIH/NHLBI (grant HL104125), EC MC ITN Project EPITRAIN (JK & MO) project and the University of Helsinki Research Funds to MO, Sigrid Juselius Foundation to MO, Yrjö Jahnsson foundation (6868) and Juho Vainio foundation to ES. TWINACTIVE study was supported by the Finnish Ministry of Education and Culture (UMK), Academy of Finland (UMK), and Juho Vainio Foundation (UMK). ...Lisenssi
Samankaltainen aineisto
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