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Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies

dc.contributor.authorFries, Martin
dc.contributor.authorMertens, Meike
dc.contributor.authorTeske, Nico
dc.contributor.authorKipp, Markus
dc.contributor.authorBeyer, Cordian
dc.contributor.authorWillms, Thomas
dc.contributor.authorValkonen, Arto
dc.contributor.authorRissanen, Kari
dc.contributor.authorAlbrecht, Markus
dc.contributor.authorClarner, Tim
dc.date.accessioned2019-01-23T07:52:20Z
dc.date.available2019-01-23T07:52:20Z
dc.date.issued2019
dc.identifier.citationFries, M., Mertens, M., Teske, N., Kipp, M., Beyer, C., Willms, T., Valkonen, A., Rissanen, K., Albrecht, M., & Clarner, T. (2019). Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies. <i>ACS Omega</i>, <i>4</i>(1), 1685-1689. <a href="https://doi.org/10.1021/acsomega.8b02523" target="_blank">https://doi.org/10.1021/acsomega.8b02523</a>
dc.identifier.otherCONVID_28876658
dc.identifier.otherTUTKAID_80407
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/62592
dc.description.abstractThe cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofseriesACS Omega
dc.rightsACS AuthorChoice
dc.subject.otherwater-soluble cuprizone derivative
dc.subject.othercharacterization
dc.subject.otherin Vitro studies
dc.titleWater-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201901221266
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemiafi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineOrganic Chemistryen
dc.contributor.oppiaineNanoscience Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-01-22T10:15:17Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1685-1689
dc.relation.issn2470-1343
dc.relation.numberinseries1
dc.relation.volume4
dc.type.versionpublishedVersion
dc.rights.copyright© 2019 American Chemical Society.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber314343
dc.subject.ysokemiallinen synteesi
dc.subject.ysoneurokemia
dc.subject.ysoamiinit
dc.subject.ysopatogeneesi
dc.subject.ysoin vitro -menetelmä
dc.subject.ysosynteesi
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p8468
jyx.subject.urihttp://www.yso.fi/onto/yso/p24603
jyx.subject.urihttp://www.yso.fi/onto/yso/p9219
jyx.subject.urihttp://www.yso.fi/onto/yso/p22207
jyx.subject.urihttp://www.yso.fi/onto/yso/p21041
jyx.subject.urihttp://www.yso.fi/onto/yso/p8467
dc.rights.urlhttp://pubs.acs.org/page/policy/authorchoice_termsofuse.html
dc.relation.doi10.1021/acsomega.8b02523
dc.relation.funderSuomen Akatemiafi
dc.relation.funderResearch Council of Finlanden
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundinginformationThis study was funded by the “Excellence Initiative of the German federal and state governments”, the Academy of Finland (A.V. grant no. 314343), and the University of Jyväskylä.
dc.type.okmA1


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