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dc.contributor.authorParmar, Priyanka
dc.contributor.authorLowry, Estelle
dc.contributor.authorCugliari, Giovanni
dc.contributor.authorSuderman, Matthew
dc.contributor.authorWilson, Rory
dc.contributor.authorKarhunen, Ville
dc.contributor.authorAndrew, Toby
dc.contributor.authorWiklund, Petri
dc.contributor.authorWielscher, Matthias
dc.contributor.authorGuarrera, Simonetta
dc.contributor.authorTeumer, Alexander
dc.contributor.authorLehne, Benjamin
dc.contributor.authorMilani, Lili
dc.contributor.authorKlein, Niek de
dc.contributor.authorMishra, Pashupati P.
dc.contributor.authorMelton, Phillip E.
dc.contributor.authorMandaviya, Pooja R.
dc.contributor.authorKasela, Silva
dc.contributor.authorNano, Jana
dc.contributor.authorZhang, Weihua
dc.contributor.authorZhang, Yan
dc.contributor.authorUitterlinden, Andre G.
dc.contributor.authorPeters, Annette
dc.contributor.authorSchöttker, Ben
dc.contributor.authorGieger, Christian
dc.contributor.authorAnderson, Denise
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorGrabe, Hans J.
dc.contributor.authorPanico, Salvatore
dc.contributor.authorVeldink, Jan H.
dc.contributor.authorvan Meurs, Joyce B.J.
dc.contributor.authorvan den Berg, Leonard
dc.contributor.authorBeilin, Lawrence J.
dc.contributor.authorFranke, Lude
dc.contributor.authorLoh, Marie
dc.contributor.authorvan Greevenbroek, Marleen M.J.
dc.contributor.authorNauck, Matthias
dc.contributor.authorKähönen, Mika
dc.contributor.authorHurme, Mikko A.
dc.contributor.authorRaitakari, Olli T.
dc.contributor.authorFranco, Oscar H.
dc.contributor.authorSlagboom, P.Eline
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorKunze, Sonja
dc.contributor.authorFelix, Stephan B.
dc.contributor.authorZhang, Tao
dc.contributor.authorChen, Wei
dc.contributor.authorMori, Trevor A.
dc.contributor.authorBonnefond, Amelie
dc.contributor.authorHeijmans, Bastiaan T.
dc.contributor.authorMuka, Taulant
dc.contributor.authorKooner, Jaspal S.
dc.contributor.authorFischer, Krista
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorFroguel, Philippe
dc.contributor.authorHuang, Rae-Chi
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorRathmann, Wolfgang
dc.contributor.authorRelton, Caroline L.
dc.contributor.authorMatullo, Giuseppe
dc.contributor.authorBrenner, Hermann
dc.contributor.authorVerweij, Niek
dc.contributor.authorLi, Shengxu
dc.contributor.authorChambers, John C.
dc.contributor.authorJärvelin, Marjo-Riitta
dc.contributor.authorSebert, Sylvain
dc.identifier.citationParmar, P., Lowry, E., Cugliari, G., Suderman, M., Wilson, R., Karhunen, V., . . . Sebert, S. (2018). Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults. <em>EBioMedicine</em>, 38, 206-216. <a href="">doi:10.1016/j.ebiom.2018.10.066</a>fi
dc.description.abstractBackground: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health. Methods: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n = 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult smoking. DNA methylation levels were analysed in relation to body mass index (BMI), waist circumference (WC), fasting glucose (FG), high-density lipoprotein cholesterol (HDL—C), triglycerides (TG), diastolic, and systolic blood pressure (BP). Findings: Lower DNA methylation at three out of eight GFI1-CpGs was associated with exposure to maternal prenatal smoking, whereas, all eight CpGs were associated with adult own smoking. Lower DNA methylation at cg14179389, the strongest maternal prenatal smoking locus, was associated with increased WC and BP when adjusted for sex, age, and adult smoking with Bonferroni-corrected P b 0·012. In contrast, lower DNA methylation at cg09935388, the strongest adult own smoking locus, was associated with decreased BMI, WC, and BP (adjusted 1 × 10−7 b P b 0.01). Similarly, lower DNA methylation at cg12876356, cg18316974, cg09662411, and cg18146737 was associated with decreased BMI and WC (5 × 10−8 b P b 0.001). Lower DNA methylation at all the CpGs was consistently associated with higher TG levels. Interpretation: Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk
dc.publisherElsevier BV
dc.rightsCC BY-NC-ND 4.0
dc.subject.othersydän- ja verisuonitauditfi
dc.subject.othermaternal prenatal smokingfi
dc.subject.othercardio-metabolic phenotypesfi
dc.titleAssociation of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adultsfi
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.rights.copyright© 2018 the Authors.

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