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dc.contributor.authorShao, Dongkai
dc.contributor.authorTapio, Kosti
dc.contributor.authorAuer, Sanna
dc.contributor.authorToppari, Jussi
dc.contributor.authorHytönen, Vesa
dc.contributor.authorAhlskog, Markus
dc.date.accessioned2019-01-07T10:14:26Z
dc.date.available2019-01-07T10:14:26Z
dc.date.issued2018
dc.identifier.citationShao, D., Tapio, K., Auer, S., Toppari, J., Hytönen, V., & Ahlskog, M. (2018). Surface characteristics control the attachment and functionality of (chimeric) avidin. <i>Langmuir</i>, <i>34</i>(50), 15335-15342. <a href="https://doi.org/10.1021/acs.langmuir.8b02855" target="_blank">https://doi.org/10.1021/acs.langmuir.8b02855</a>
dc.identifier.otherCONVID_28710584
dc.identifier.otherTUTKAID_79448
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/60937
dc.description.abstractThe physical adsorption (physisorption) of proteins to surfaces is an important but incompletely understood factor in many biological processes and is of increasing significance in bionanotechnology as well. Avidin is an important protein because of strong avidin–biotin binding, which has been exploited in numerous applications. We have undertaken thorough experimentation on the physisorption of avidin, to chemically different flat surfaces of Si and graphite and also to the curved version of the latter, on multiwalled carbon nanotubes (MWNTs) of different diameters. The difference in the behavior of avidin on Si versus graphite is drastic; on Si, avidin deposits as single globular tetrameric units and maintains functionality, whereas on graphite, it forms irregular networks of two-layer thick filaments, where the first layer has lost its biological activity. On MWNTs, avidin also deposits as one-dimensional formations, or stripes, but these appear to order in a perpendicular arrangement to the MWNT axis. A better understanding of protein–surface interactions is essential for the development of robust and reliable methods for biofunctionalization of materials. This work also provides insights into the importance of the nanoscale surface architecture.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofseriesLangmuir
dc.rightsACS Author Choice
dc.subject.otherinterface components
dc.subject.othersurfactants
dc.titleSurface characteristics control the attachment and functionality of (chimeric) avidin
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201812215317
dc.contributor.laitosFysiikan laitosfi
dc.contributor.laitosDepartment of Physicsen
dc.contributor.oppiaineFysiikkafi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiainePhysicsen
dc.contributor.oppiaineNanoscience Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-12-21T10:15:12Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange15335-15342
dc.relation.issn0743-7463
dc.relation.numberinseries50
dc.relation.volume34
dc.type.versionacceptedVersion
dc.rights.copyright© 2018 American Chemical Society.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber283011
dc.subject.ysonanohiukkaset
dc.subject.ysopolymeerit
dc.subject.ysokolloidit
dc.subject.ysoproteiinit
dc.subject.ysoemulsiot
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23451
jyx.subject.urihttp://www.yso.fi/onto/yso/p926
jyx.subject.urihttp://www.yso.fi/onto/yso/p8837
jyx.subject.urihttp://www.yso.fi/onto/yso/p4332
jyx.subject.urihttp://www.yso.fi/onto/yso/p12243
dc.rights.urlhttps://pubs.acs.org/page/policy/authorchoice_termsofuse.html
dc.relation.doi10.1021/acs.langmuir.8b02855
dc.relation.funderSuomen Akatemiafi
dc.relation.funderResearch Council of Finlanden
jyx.fundingprogramAkatemiaohjelma, SAfi
jyx.fundingprogramAcademy Programme, AoFen
jyx.fundinginformationThis work was financially supported by the Academy of Finland through projects 263526, 130900, and 283011 for J.J.T., 263540 and 290506 for V.P.H., and 263523 for M.A.
dc.type.okmA1


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