MicroRNA-21, -126 and -146a as potential novel systemic markers of metabolic syndrome
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
Obesity and overweight have reached epidemic proportions. These conditions increase the risk of numerous health problem, including metabolic syndrome (MetS). Hormonal changes during menopause transition may be related to the increased frequency of the MetS. Circulating microRNAs (miRNAs) are easily detectable in blood and have a potential to act as non-invasive biomarkers. MiR-21, miR-126, and miR-146a were selected in this Master’s thesis because they are associated with MetS risk factors and menopause-related hormone estradiol (E2). Hypothesis of this study was that circulating miR-21, miR-126 and miR-146a levels may vary in different MetS risk factor groups and stage of menopause. Participants (n=137) were divided to the MetS risk factor groups; healthy (n=35), risk 1 (n=35), risk 2 (n=33), and MetS (n=34), based on anthropometrics and measured blood characteristics. Menopause groups; pre- (n=45), peri- (n=44) and postmenopause (n=48) were divided based on blood test and menstrual diary. Circulating miRNAs levels were quantified with quantitative polymerase chain reaction (qPCR). The results could not establish distinct association between serum miR-21, miR-126 and miR-146a to the risk factor groups of MetS or to the stage of menopause. However, significant correlation was observed between miR-21 and E2, miR-21 and glucose and miR-126 and glucose. Based on the results of this thesis, despite the associations found between miRNAs and glucose, the studied miRNAs cannot be considered as markers of MetS. ...
MetadataShow full item record
- Pro gradu -tutkielmat 
Showing items with similar title or keywords.
Aging and microRNA messaging : associations with systemic estrogen levels and physical performance Kangas, Reeta (University of Jyväskylä, 2018)This thesis took an innovative approach, which involved methodological development, to investigate microRNAs as candidate molecules and as genome-wide regulators of age, menopausal status and physical condition in both ...
The potential role of circulating-micro-RNA-21, -146a, -221 and -222 as non-invasive biomarkers in acute exercise training Sievänen, Tero (2019)Elimistössä kiertävät mikro-RNAt (ci-miRNAt) säätelevät geenien toimintaa ja toimivat viestimolekyyleinä kudosten välillä. Tämän vuoksi niitä on mahdollista hyödyntää merkkimolekyyleinä mm. tutkittaessa liikunnan aiheuttamia ...
Wiklund, Petri; Pekkala, Satu; Autio, Reija; Munukka, Eveliina; Xu, Leiting; Saltevo, Juha; Cheng, Shumei; Kujala, Urho; Alen, Markku; Cheng, Sulin (BioMed Central Ltd., 2014)Objective: To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body ...
Effects of a weight management program delivered by social media on weight and metabolic syndrome risk factors in overweight and obese adults : A randomised controlled trial Jane, Monica; Hagger, Martin; Foster, Jonathan; Ho, Suleen; Kane, Robert; Pal, Sebely (Public Library of Science, 2017)Introduction The aim of this project was to evaluate the effectiveness of using social media to augment the delivery of, and provide support for, a weight management program delivered to overweight and obese individuals ...
Effects of a short-term resistance training protocol on risk factors for the metabolic syndrome in the elderly Inglis, Alistair (2016)The metabolic syndrome is strongly associated with negative health outcomes, such as type 2 diabetes, cardiovascular disease and death. The elderly are at particularly high risk of developing the metabolic syndrome, owing ...