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dc.contributor.authorSelin, Markus
dc.contributor.authorNummelin, Sami
dc.contributor.authorDeleu, Jill
dc.contributor.authorRopponen, Jarmo
dc.contributor.authorViitala, Tapani
dc.contributor.authorLahtinen, Manu
dc.contributor.authorKoivisto, Jari
dc.contributor.authorHirvonen, Jouni
dc.contributor.authorPeltonen, Leena
dc.contributor.authorKostiainen, Mauri A.
dc.contributor.authorBimbo, Luis M.
dc.date.accessioned2018-10-26T11:50:09Z
dc.date.available2019-08-29T21:35:19Z
dc.date.issued2018
dc.identifier.citationSelin, M., Nummelin, S., Deleu, J., Ropponen, J., Viitala, T., Lahtinen, M., Koivisto, J., Hirvonen, J., Peltonen, L., Kostiainen, M. A., & Bimbo, L. M. (2018). High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions. <i>Biomacromolecules</i>, <i>19</i>(10), 3983-3993. <a href="https://doi.org/10.1021/acs.biomac.8b00931" target="_blank">https://doi.org/10.1021/acs.biomac.8b00931</a>
dc.identifier.otherCONVID_28231667
dc.identifier.otherTUTKAID_78640
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59966
dc.description.abstractPharmaceutical nanosuspensions are formed when drug crystals are suspended in aqueous media in the presence of stabilizers. This technology offers a convenient way to enhance the dissolution of poorly water-soluble drug compounds. The stabilizers exert their action through electrostatic or steric interactions, however, the molecular requirements of stabilizing agents have not been studied extensively. Here, four structurally related amphiphilic Janusdendrimers were synthesized and screened to determine the roles of different macromolecular domains on the stabilization of drug crystals. Physical interaction and nanomilling experiments have substantiated that Janus-dendrimers with fourth generation hydrophilic dendrons were superior to third generation analogues and Poloxamer 188 in stabilizing indomethacin suspensions. Contact angle and surface plasmon resonance measurements support the hypothesis that Janus-dendrimers bind to indomethacin surfaces via hydrophobic interactions and that the number of hydrophobic alkyl tails determines the adsorption kinetics of the Janus-dendrimers. The results showed that amphiphilic Janus-dendrimers adsorb onto drug particles, and thus can be used to provide steric stabilization against aggregation and recrystallization. The modular synthetic route for new amphiphilic Janus-dendrimers offers thus, for the first time, a versatile platform for stable general-use stabilizing agents of drug suspensions.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofseriesBiomacromolecules
dc.rightsIn Copyright
dc.subject.otherlääkeyhdisteet
dc.subject.otherfarmaseuttinen kemia
dc.subject.otherpharmaceutical nanosuspensions
dc.titleHigh-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201810084383
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineEpäorgaaninen ja analyyttinen kemiafi
dc.contributor.oppiaineInorganic and Analytical Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-10-08T12:15:11Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange3983-3993
dc.relation.issn1525-7797
dc.relation.numberinseries10
dc.relation.volume19
dc.type.versionacceptedVersion
dc.rights.copyright© 2018 American Chemical Society
dc.rights.accesslevelopenAccessfi
dc.subject.ysolääkkeet
dc.subject.ysohuumeet
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p1077
jyx.subject.urihttp://www.yso.fi/onto/yso/p5465
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1021/acs.biomac.8b00931
dc.type.okmA1


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