Glucose regulation and physical performance among older people : the Helsinki Birth Cohort Study
Åström, M. J., von Bonsdorff, M., Perälä, M. M., Salonen, M. K., Rantanen, T., Kajantie, E., Simonen, M., Pohjolainen, P., Osmond, C., & Eriksson, J. G. (2018). Glucose regulation and physical performance among older people : the Helsinki Birth Cohort Study. Acta Diabetologica, 55(10), 1051-1058. https://doi.org/10.1007/s00592-018-1192-1
Published in
Acta DiabetologicaAuthors
Date
2018Discipline
Gerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of WellbeingCopyright
© The Authors 2018
Aims
To assess whether disturbances in glucose regulation are associated with impairment in physical performance during a 10-year follow-up.
Methods 475 Men and 603 women from the Helsinki Birth Cohort Study were studied. Glucose regulation was evaluated with a 2-h 75-g oral glucose tolerance test (OGTT) in 2001–2004. Subjects were categorised as having either impaired fasting glucose (IFG), impaired glucose tolerance (IGT), newly diagnosed diabetes or previously known diabetes. Physical performance was assessed approximately 10 years later using the validated senior fitness test (SFT). The relationship between glucose regulation and the overall SFT score was estimated using multiple linear regression models.
Results
The mean age was 70.8 years for men and 71.0 years for women when physical performance was assessed. The mean SFT score for the whole population was 45.0 (SD 17.5) points. The SFT score decreased gradually with increased impairment in glucose regulation. Individuals with previously known diabetes had the lowest overall SFT score in the fully adjusted model (mean difference compared to normoglycaemic individuals −11.56 points, 95% CI − 16.15 to − 6.98, p<0.001). Both individuals with newly diagnosed diabetes and individuals with IGT had significantly poorer physical performance compared to those with normoglycaemia. No significant difference in physical performance was found between those with IFG and those with normoglycaemia.
Conclusions
Among older people, impaired glucose regulation is strongly related with poor physical performance. More
severe disturbances in glucose regulation are associated with a greater decrease in physical function, indicating the importance of diagnosing these disturbances at an early stage.
...
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SpringerISSN Search the Publication Forum
0940-5429Keywords
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