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dc.contributor.authorSiitonen, Juha
dc.date.accessioned2018-09-14T10:06:00Z
dc.date.available2018-09-14T10:06:00Z
dc.date.issued2018
dc.identifier.isbn978-951-39-7551-7fi
dc.identifier.isbn978-951-39-7551-7
dc.identifier.otheroai:jykdok.linneanet.fi:1893932
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59525
dc.description.abstractThe first chapter introduces the reader to the concept of natural product total synthesis and its importance to chemistry, other sciences, and society. The second chapter reviews the chemistry of natural products containing 1-azabicyclo[5.3.0]decane motifs. This bicyclic motif and the natural products related to it, have been a continuous source of synthetic inspiration over the last decades. The second chapter of the thesis reviews the strategies and tactics developed. The third chapter covers the author’s total synthesis of stemoamide, a 1-azabicyclo[5.3.0]decane motif containing alkaloid. Additionally, two diastereomers of stemoamide were synthesized, allowing their structural reassignment. Tentative studies towards a divergent route to other stemona alkaloids from a key precursor were also carried out. The fourth chapter targets another 1-azabicyclo[5.3.0]decane alkaloid, cephalotaxine. These are the results of a four-month exchange to the group of Prof. Peter Somfai at Lund University. After various challenges, a short and facile formal total synthesis relying on a cascade cyclization was developed. The fifth chapter briefly restates the main conclusions of chapters two, three and four, and contemplates on the future of the field. Chapters six and seven contain experimental and computational details, respectively.fi
dc.format.extent1 verkkoaineisto (142 sivua) kuvitettu
dc.language.isoeng
dc.publisherUniversity of Jyväskylä
dc.relation.ispartofseriesResearch report / Department of Chemistry. University of Jyväskylä
dc.subject.otherkokonaissynteesi
dc.subject.othertotal synthesis
dc.subject.othernatural products
dc.subject.otheralkaloids
dc.subject.otherstemona
dc.subject.othercephalotaxus
dc.titleSynthetic studies on 1-azabicyclo[5.3.0]decane alkaloids
dc.typeDiss.
dc.identifier.urnURN:ISBN:978-951-39-7551-7
dc.contributor.yliopistoUniversity of Jyväskyläen
dc.contributor.yliopistoJyväskylän yliopistofi
dc.contributor.oppiaineKemiafi
dc.relation.issn0357-346X
dc.relation.numberinseriesNo. 210
dc.rights.accesslevelopenAccess
dc.subject.ysokemiallinen synteesi
dc.subject.ysoluonnonaineet
dc.subject.ysoalkaloidit
dc.rights.accessrights


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