Näytä suppeat kuvailutiedot

dc.contributor.authorLaaksonen, Marko S.
dc.contributor.authorKyröläinen, Heikki
dc.contributor.authorKemppainen, Jukka
dc.contributor.authorKnuuti, Juhani
dc.contributor.authorKalliokoski, Kari
dc.date.accessioned2018-08-22T12:36:15Z
dc.date.available2018-08-22T12:36:15Z
dc.date.issued2018
dc.identifier.citationLaaksonen, M. S., Kyröläinen, H., Kemppainen, J., Knuuti, J., & Kalliokoski, K. (2018). Muscle free fatty-acid uptake associates to mechanical efficiency during exercise in humans. <i>Frontiers in Physiology</i>, <i>9</i>, Article 1171. <a href="https://doi.org/10.3389/fphys.2018.01171" target="_blank">https://doi.org/10.3389/fphys.2018.01171</a>
dc.identifier.otherCONVID_28213906
dc.identifier.otherTUTKAID_78540
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59315
dc.description.abstractIntrinsic factors related to muscle metabolism may explain the differences in mechanical efficiency (ME) during exercise. Therefore, this study aimed to investigate the relationship between muscle metabolism and ME. Totally 17 healthy recreationally active male participants were recruited and divided into efficient (EF; n = 8) and inefficient (IE; n = 9) groups, which were matched for age (mean ± SD 24 ± 2 vs. 23 ± 2 years), BMI (23 ± 1 vs. 23 ± 2 kg m−2), physical activity levels (3.4 ± 1.0 vs. 4.1 ± 1.0 sessions/week), and V˙O2peak (53 ± 3 vs. 52 ± 3 mL kg−1 min−1), respectively, but differed for ME at 45% of V˙O2peak intensity during submaximal bicycle ergometer test (EF 20.5 ± 3.5 vs. IE 15.4 ± 0.8%, P < 0.001). Using positron emission tomography, muscle blood flow (BF) and uptakes of oxygen (mV˙O2), fatty acids (FAU) and glucose (GU) were measured during dynamic submaximal knee-extension exercise. Workload-normalized BF (EF 35 ± 14 vs. IE 34 ± 11 mL 100 g−1 min−1, P = 0.896), mV˙O2 (EF 4.1 ± 1.2 vs. IE 3.9 ± 1.2 mL 100 g−1 min−1, P = 0.808), and GU (EF 3.1 ± 1.8 vs. IE 2.6 ± 2.3 μmol 100 g−1 min−1, P = 0.641) as well as the delivery of oxygen, glucose, and FAU, as well as respiratory quotient were not different between the groups. However, FAU was significantly higher in EF than IE (3.1 ± 1.7 vs. 1.7 ± 0.6 μmol 100 g−1 min−1, P = 0.047) and it also correlated with ME (r = 0.56, P = 0.024) in the entire study group. EF group also demonstrated higher use of plasma FAU than IE, but no differences in use of plasma glucose and intramuscular energy sources were observed between the groups. These findings suggest that the effective use of plasma FAU is an important determinant of ME during exercise.fi
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofseriesFrontiers in Physiology
dc.rightsCC BY 4.0
dc.subject.otherfree fatty-acid
dc.subject.otherskeletal muscle
dc.titleMuscle free fatty-acid uptake associates to mechanical efficiency during exercise in humans
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201808213892
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineExercise Physiologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-08-21T12:15:11Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1664-042X
dc.relation.numberinseries0
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysorasvahapot
dc.subject.ysoaineenvaihdunta
dc.subject.ysoluusto
dc.subject.ysolihakset
dc.subject.ysohapenotto
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p4800
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
jyx.subject.urihttp://www.yso.fi/onto/yso/p7233
jyx.subject.urihttp://www.yso.fi/onto/yso/p2784
jyx.subject.urihttp://www.yso.fi/onto/yso/p25455
dc.rights.urlhttp://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fphys.2018.01171
dc.type.okmA1


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